@misc{oai:repo.qst.go.jp:00073045,
 author = {wang, BIng and Tanaka, Kaoru and Katsube, Takanori and Ninomiya, Yasuharu and Hirakawa, Hirokazu and Liu, Cuihua and Maruyama, Kouichi and Vares, Guillaume and Liu, Qing and Nakajima, Tetsuo and Fujimori, Akira and Nenoi, Mitsuru and 王 冰 and 田中 薫 and 勝部 孝則 and 二宮 康晴 and 平川 博一 and 劉 翠華 and 丸山 耕一 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 中島 徹夫 and 藤森 亮 and 根井 充},
 month = {Sep},
 note = {Exposure to either ionizing radiation or psychological stress (PS) could cause detrimental effects on humans. The RBE of high atomic number and energy particles such as Fe ions from the galactic cosmic rays and solar particle events is usually higher than low LET gamma or X-rays. A pioneering study showed that chronic restraint-induced PS (CRIPS) could attenuate Trp53 functions and increase carcinogenesis induced by low LET gamma-rays in Trp53-heterozygous (Trp53+/-) mice.
Prior to a carcinogenesis study, we further investigated the modification effects from CRIPS on radiation-induced deterministic effects in the hematopoietic system in a mouse CRIPS model. We reported previously that in Trp53 wild type (Trp53wt) animals receiving total body irradiation (TBI) with low LET X-rays, CRIPS did not have a significant impact on radiation-induced detrimental effects.
In this work, Trp53+/- mice were given both CRIPS and accelerated Fe ions. Results showed that CRIPS alone hardly induce marked alteration in hematological parameters in the peripheral blood and the formation of micronucleated erythrocytes in the bone marrow while Fe TBI alone could induce significant hematological alteration and increased micronucleated erythrocytes. On the other hand, concurrent exposure of the animals to CRIPS and Fe TBI always showed a tendency of increased micronucleated erythrocytes when compared to the animals receiving only Fe TBI, and the increase was statistically significant for the mice receiving Fe TBI at 0.1 Gy. These findings suggest that concurrent exposure to CRIPS and high LET Fe, particularly at low doses, may have a significant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53+/- mice. At this annual meeting, the details of the results will be introduced.
This work was partially supported by both the Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas, Grant Numbers JP15K21745 and 15H05935 “Living in Space” and 3 HIMAC Research Project Grants (22B258, 14J286 and 16J295). The expert technical assistance and administrative support of Ms. Hiromi Arai, Mr. Sadao Hirobe, Ms. Mikiko Nakajima, and Ms. Yasuko Morimoto are gratefully acknowledged., The 64th Annual Radiation Research Society MeetingRRS 2018 学会参加して 「Effects from chronic restraint-induced stress and total body Fe irradiation on the hematopoietic system in Trp53-heterozygous mice.」のタイトルで ポスター発表を行う。},
 title = {Effects from chronic restraint-induced stress and total body Fe irradiation on the hematopoietic system in Trp53-heterozygous mice.},
 year = {2018}
}