{"created":"2023-05-15T14:53:37.016471+00:00","id":73016,"links":{},"metadata":{"_buckets":{"deposit":"96cf40da-bbf1-40b2-b5da-eed2f5630f32"},"_deposit":{"created_by":1,"id":"73016","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"73016"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00073016","sets":["10:28"]},"author_link":["719569","719562","719564","719561","719566","719565","719570","719568","719563","719567"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-11-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"放射線適応応答とは、あらかじめ低線量の放射線照射をすることで、その後の高線量の放射線照射に対し抵抗性を持つ生体応答である。過去の研究より、放射線適応応答の重要な誘導経路内に、正・負のフィードバック回路の存在が示唆されている。本研究では、実験及び、モデル化を利用したシステム生物学的な解析を用いて、放射線適応応答のメカニズム解明を目指す。細胞内のCa²⁺濃度のオシレーションが放射線適応応答の誘導に必要であるという作業仮説の元、キレート剤添加によるCa²⁺濃度の制御と、さらには薬剤によるCa²⁺オシレーション誘導を試み、これらの外部刺激による放射線適応応答の変化について調べ、モデル化に必要なパラメータ獲得を試みたので報告する。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第61回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉本, 理峻"}],"nameIdentifiers":[{"nameIdentifier":"719561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"濱田, 涼"}],"nameIdentifiers":[{"nameIdentifier":"719562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"服部, 佑哉（東京工業大学工学院システム制御系）"}],"nameIdentifiers":[{"nameIdentifier":"719563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横谷, 立子"}],"nameIdentifiers":[{"nameIdentifier":"719564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"立花, 章（茨城大学理学部）"}],"nameIdentifiers":[{"nameIdentifier":"719565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横谷, 明徳"}],"nameIdentifiers":[{"nameIdentifier":"719566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"杉本 理峻","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"719567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"濱田 涼","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"719568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横谷 立子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"719569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横谷 明徳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"719570","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Ca²⁺濃度変化をパラメータとする放射線適応応答反応ネットワークのモデル化の試み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ca²⁺濃度変化をパラメータとする放射線適応応答反応ネットワークのモデル化の試み"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-15"},"publish_date":"2018-11-15","publish_status":"0","recid":"73016","relation_version_is_last":true,"title":["Ca²⁺濃度変化をパラメータとする放射線適応応答反応ネットワークのモデル化の試み"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:33:40.448975+00:00"}