{"created":"2023-05-15T14:53:32.924105+00:00","id":72922,"links":{},"metadata":{"_buckets":{"deposit":"a96a85ab-1998-4241-a48d-dd0c2b2e8eef"},"_deposit":{"created_by":1,"id":"72922","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72922"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072922","sets":["10:28"]},"author_link":["718553","718552","718550","718554","718551","718555"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-09-07","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"  Hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy (MRS) is an emerging technique that allows noninvasive detection of metabolic conversion  of  [1-13C]pyruvate  to  [1-13C]lactate in tissues or cells depending on the over  10,000-fold  enhanced 13C NMR signals. This enables chemical-shift imaging (CSI) of lactate formation from pyruvate that is significantly higher in tumors compared with normal tissues. While, recent development of tissue engineering has realized the induction of tissue-like features even in vitro, such as 3D spheroidal culture of tumor cells. This engineered tumor tissue mimetics, put in an NMR tube, may allow noninvasive assessment of the glycolytic potential in tumors grown on living animals. In this work, a strategy for hyperpolarized [1-13C]pyruvate MRS of tumor spheroids was established using murine squamous cell carcinoma (SCCVII) and PSA-negative prostate tumor cells (DU145, PC-3). Using this method, metabolic properties in cell spheroids were compared with those in normal cells cultured as monolayer.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"TERMIS - 5th Tissue Engineering and Regenerative Medicine International Society World Congress","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takakusagi, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"718550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"718551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"718552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichikawa, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"718553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高草木 洋一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"718554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高草木 香織","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"718555","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Use of hyperpolarized magnetic resonance spectroscopy (HP-MRS) in cell and tissue engineering","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Use of hyperpolarized magnetic resonance spectroscopy (HP-MRS) in cell and tissue engineering"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-10"},"publish_date":"2018-09-10","publish_status":"0","recid":"72922","relation_version_is_last":true,"title":["Use of hyperpolarized magnetic resonance spectroscopy (HP-MRS) in cell and tissue engineering"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:34:38.403840+00:00"}