{"created":"2023-05-15T14:53:26.723839+00:00","id":72781,"links":{},"metadata":{"_buckets":{"deposit":"838c6275-c2e8-48d2-94c2-9237dff357ca"},"_deposit":{"created_by":1,"id":"72781","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72781"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072781","sets":["10:28"]},"author_link":["717071","717068","717049","717065","717057","717059","717070","717063","717054","717062","717050","717053","717055","717047","717069","717067","717066","717061","717056","717064","717051","717060","717046","717048","717052","717058"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-04-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Cytoreductive surgery is widely used for the treatment of peritoneal dissemination in clinical practice; however, it is difficult to detect and remove tumors that are located deeply in the peritoneal cavity and easily changing the position during an operation. We have found that a PET probe 64Cu-PCTA-anti-EGFR antibody cetuximab (64Cu-cetuximab) highly accumulates in intraperitoneal tumors by intraperitoneal administration. Also, we have developed the world's first open-type PET system, called \"OpenPET\", which has open space for conducting surgery while monitoring objects at high resolution in real time. In this study, we examined a feasibility of an OpenPET-guided surgery with 64Cu-cetuximab to detect and remove tumors deeply located in the peritoneal cavity. Methods: Mice bearing HCT116-RFP tumors transplanted with Matrigel at deep sites in the peritoneal cavity were used. 64Cu-cetuximab (7.4 MBq / mouse) was administered intraperitoneally and at 24 h later, the OpenPET-guided surgery was performed with a small prototype of OpenPET, having a spatial resolution of about 2 mm. All animal experiments were approved by the institutional ethics committee. Results: During OpenPET-guided surgery, tumors were clearly detected behind other organs in the peritoneal cavity. The measurement time required to accumulate sufficient data to identify tumors was approximately 10 – 30 s. Tumors (≥ 3 mm in diameter) located deep inside the peritoneal cavity could be resected by surgery with OpenPET real-time imaging. OpenPET was useful in confirming the presence or absence of residual tumors during an operation. Conclusions: We demonstrated that the OpenPET-guided surgery with 64Cu-cetuximab would be promising to detect and remove intraperitoneal tumors deeply located in the peritoneal cavity. This method could provide a novel strategy for cytoreductive surgery of peritoneal dissemination.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"12th World congress of the world federation of nuclear medicine and biology","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshii, Yukie"}],"nameIdentifiers":[{"nameIdentifier":"717046","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tashima, Hideaki"}],"nameIdentifiers":[{"nameIdentifier":"717047","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwao, Yuma"}],"nameIdentifiers":[{"nameIdentifier":"717048","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takuwa, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"717049","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Eiji"}],"nameIdentifiers":[{"nameIdentifier":"717050","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu"}],"nameIdentifiers":[{"nameIdentifier":"717051","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaya, Taiga"}],"nameIdentifiers":[{"nameIdentifier":"717052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimoto, Mitsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"717053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"717054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"717055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugyo, Aya"}],"nameIdentifiers":[{"nameIdentifier":"717056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"717057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"717058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田島 英朗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717060","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩男 悠真","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田桑 弘之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 英治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山谷 泰賀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉本 光喜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 博樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717071","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Evaluation of a PET-guided surgery with 64Cu-labeled cetuximab to resect tumors deeply located in the mouse peritoneal cavity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of a PET-guided surgery with 64Cu-labeled cetuximab to resect tumors deeply located in the mouse peritoneal cavity"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-10"},"publish_date":"2018-05-10","publish_status":"0","recid":"72781","relation_version_is_last":true,"title":["Evaluation of a PET-guided surgery with 64Cu-labeled cetuximab to resect tumors deeply located in the mouse peritoneal cavity"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:36:08.142607+00:00"}