{"created":"2023-05-15T14:53:25.767805+00:00","id":72759,"links":{},"metadata":{"_buckets":{"deposit":"2a6a8571-6030-4293-b294-b219c7bd0872"},"_deposit":{"created_by":1,"id":"72759","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72759"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072759","sets":["10:28"]},"author_link":["716651","716648","716649","716658","716644","716656","716653","716654","716647","716646","716650","716652","716645","716655","716657"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-04-23","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and Aims:  Capturing host antitumor responses to combinatorial immunotherapy remains a major challenge. From the standpoint of immunology, cancer immunotherapy is considered as a “double edged sword” in that it can trigger two opposite immunologic processes to limit potential toxicity associated with excessive response [1]. So tracking its opposite immune regulatory-mechanisms has potential as surrogates for defining the complex scenarios. In this study, we developed a small-molecular positron emission tomography/computed tomography (PET/CT) method targeting the checkpoint protein, IDO1, in tumor-bearing hosts to address this challenge. \n\\nMethods: Leveraging the very short-lived positron emitter carbon-11 (11C; half-life: 20.4 min) to label a small molecule IDO1 inhibitor, levorotary (L) form of 1-methyl-tryptophan (1MTrp), we developed a radioprobe 1-N-11C-methyl-L-tryptophan (11C-L-1MTrp) [2]. Using PET/CT with 11C-L-1MTrp, we specifically and serially monitored IDO1 changes to reveal the antitumor immune response in melanoma-bearing immunocompetent mice treated with immunotherapy combinatorial chemotherapy. Animal studies were approved by the Animal Ethics Committee of the National Institutes for Quantum and Radiological Science and Technology.\n\\nResults: On combining the 11C-L-1MTrp and the imaging power of PET/CT, we observed that IDO1 exhibited dynamic alterations in mesenteric lymph nodes (MLN) and the caput of the epididymis, and observed a connection between active responses to combinatorial immunotherapy in immunocompetent mice. These imaging markers exhibited an empirical cut-off value of 7.023 %ID/g for radioactivity in MLN, which provided an early-on-treatment indicator with 97.92 % specificity. A cut-off value of 8.313 %ID/g in the epididymis offered a sensitivity of 100 % as an index of immune exhaustion. \n\\nConclusion: 11C-L-1MTrp-PET/CT provided a visual method to capture the dynamics of host responses to combinatorial immunotherapies, with near-term clinical application. \n\\nReferences: [1]. Pardoll DM. Nature Rev. Cancer. 2012, 12, 252. [2] Xie, L. et al. Sci. Rep.2015, 5,16417.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"12th World Congress of the World Federation of Nuclear Medicine and Biology","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Xie, Lin"}],"nameIdentifiers":[{"nameIdentifier":"716644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"716645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding"}],"nameIdentifiers":[{"nameIdentifier":"716646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jiang, Cuiping"}],"nameIdentifiers":[{"nameIdentifier":"716647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu"}],"nameIdentifiers":[{"nameIdentifier":"716648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"716649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki"}],"nameIdentifiers":[{"nameIdentifier":"716650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"716651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"716652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"716653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"716654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"716655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"716656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"716657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"716658","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Visualizing the dynamics of checkpoint protein IDO1 reveals host antitumor responses activated by a combination of immunotherapy and chemotherapy with 11C-L-1MTrp PET","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Visualizing the dynamics of checkpoint protein IDO1 reveals host antitumor responses activated by a combination of immunotherapy and chemotherapy with 11C-L-1MTrp PET"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-27"},"publish_date":"2018-04-27","publish_status":"0","recid":"72759","relation_version_is_last":true,"title":["Visualizing the dynamics of checkpoint protein IDO1 reveals host antitumor responses activated by a combination of immunotherapy and chemotherapy with 11C-L-1MTrp PET"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:36:23.252546+00:00"}