@misc{oai:repo.qst.go.jp:00072719,
 author = {Matsumoto, Ken-ichiro and B., Mitchell James and C., Krishna Murali and 松本 謙一郎},
 month = {Jul},
 note = {Effect of oxygenation challenges to the in vivo decay constants of nitroxyl contrast agents in tumor tissue and normal muscle were investigated. Three nitroxyl contrast agents, 3-carboxy-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CxP), 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CmP), and 4-hydroxy-tetramethylpiperidine-N-oxyl (TPL), having different lipophilicities were compared using MR redox imaging. The MR signal decay rate of CxP was slower in tumor tissue than normal tissue, while the decay rates of CmP and TPL were faster in tumor tissue than normal tissue. Exposure to 100% oxygen made decay rate of TPL in tumor tissue faster, but not significantly. No marked effect was obtained on decay rate of TPL in normal muscle. In addition, 100% oxygen challenging make maximum T1 enhancement induced by TPL in tumor tissue lower but not significant. Oxygen challenges gave no marked effect on the nitroxyl-induced maximum T1 enhancement in the normal tissue. Breathing 100% oxygen could make the concentration difference of TPL between tumor and normal tissues larger. The EPR linewidth of TPL in normal tissue was increased by Carbogen breathing, while 100% oxygen breathing reduced the EPR linewidth of TPL. A combination of 100% oxygen and TPL has a potential to enhance both the radio-sensitization effect to tumor tissue and the radioprotection effect to normal tissue., 1st QST International Symposium -Quantum Life Science-},
 title = {Effect of Breathing Gas to the Decay Constant of Nitroxyl Contrast Agents in Tumorous Tissue: Assessment using MR Redox Imaging},
 year = {2017}
}