{"created":"2023-05-15T14:53:23.877447+00:00","id":72716,"links":{},"metadata":{"_buckets":{"deposit":"9e2c927b-baef-4d98-be42-aa29f6919509"},"_deposit":{"created_by":1,"id":"72716","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72716"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072716","sets":["10:28"]},"author_link":["716242","716243"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-02-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and Aims: 11C-PBB3 is a tau PET ligand that can visualize diverse tau pathologies including Alzheimer’s disease (AD), non-AD tauopathies, and tau transgenic mice. We have developed a 18F-labeled PBB3 derivative, 18F-PM-PBB3. To evaluate the potential utility of this ligand in clinical trials of tau targeting agents, we conducted preclinical and clinical studies using 18F-PM-PBB3.\nMethods: Preclinical characterization of 18F-PM-PBB3 was performed using brain samples of humans and model mice. To perform head-to-head comparison between 18F-PM-PBB3 and 11C-PBB3, patients with AD and progressive supranuclear palsy (PSP), and cognitively healthy subjects underwent PET scans with 18F-PM-PBB3 and 11C-PBB3.\nResults: Preclinical evaluations demonstrated that 18F-PM-PBB3 can bind diverse tau pathologies, including AD, PSP, corticobasal degeneration and Pick’s disease, with high sensitivity and specificity. In clinical PET study, dynamic ranges of 18F-PM-PBB3 yield about 2-fold higher than 11C-PBB3 in visualizing tau lesions, while distribution patterns of specific binding are similar. 18F-PM-PBB3 does not produce prominent off-target signals in basal ganglia. Standardized uptake value ratios can be used as robust and simplified indices of the specific binding.\nConclusions: 18F-PM-PBB3 is a promising PET ligand for quantifying tau pathologies in AD and non-AD patients with suitable pharmacokinetics and high contrast.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"13th Annual Biomarkers Congress","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"716242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"716243","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Potential utility of novel tau PET ligand, 18F-PM-PBB3","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Potential utility of novel tau PET ligand, 18F-PM-PBB3"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-22"},"publish_date":"2018-03-22","publish_status":"0","recid":"72716","relation_version_is_last":true,"title":["Potential utility of novel tau PET ligand, 18F-PM-PBB3"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:36:51.339700+00:00"}