{"created":"2023-05-15T14:53:18.851906+00:00","id":72604,"links":{},"metadata":{"_buckets":{"deposit":"3f6d664f-ecfb-4b58-8c6a-025b4d41fdd8"},"_deposit":{"created_by":1,"id":"72604","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72604"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072604","sets":["10:28"]},"author_link":["715098","715088","715096","715107","715090","715083","715092","715093","715086","715104","715100","715084","715102","715094","715099","715091","715085","715087","715106","715089","715105","715095","715103","715097","715101"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-11-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的：発症前 Alzheimer病（AD）スペクトラム患者における11C-PBB3を用いたタウPETの経時的変化と臨床的有用性について検討した。\n方法：対象は過去に11C-PBB3および11C-PiBでタウおよびアミロイド病変の PET撮像を行った健常高齢者8例（PiB陰性6例、陽性2例）、軽度認知機能障害（MCI）患者4例（全例PiB陽性）。本研究は倫理委員会より承認を得た。全被験者から研究参加の同意を書面で得た。平均2年間隔で11C-PBB3および11C-PiB PETの再撮像を行い、小脳皮質を参照領域としたStandard Uptake Value Ratio（SUVR）画像を作製し、局所のタウおよびアミロイド蓄積量の指標とした。全大脳皮質、およびタウ病理のBraak仮説に準じて設定した関心領域におけるSUVRの変化と、臨床症状との関連を検討した。\n結果：初回撮像時でPiB陽性であった健常高齢者2例がMCIへ、およびMCI2例がADへの進行を認め、これら6例で、全大脳皮質およびBraak V/VI領域における11C-PBB3 SUVRの有意な増加を認めた。重回帰分析では初回撮像時での全大脳皮質11C-PBB3 SUVRはClinical Dementia Rating Scale Sum of Boxes Scoresの年間変化率と関連していた（p＜0.05）。\n考察：健常加齢からMCIひいてはADに至る過程で、特にBraak stage V/VIを特徴づける大脳新皮質領域におけるタウ蓄積の増加が顕著で、臨床的な進行に関連すると考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第36回 日本認知症学会 学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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裕平"}],"nameIdentifiers":[{"nameIdentifier":"715089","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"仲野, 義和"}],"nameIdentifiers":[{"nameIdentifier":"715090","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井, 辰弥"}],"nameIdentifiers":[{"nameIdentifier":"715091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"715092","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"繁田, 雅弘"}],"nameIdentifiers":[{"nameIdentifier":"715093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"715094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"715095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"互 健二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村 聡一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑 圭輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保田 学","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高堂 裕平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"仲野 義和","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 辰弥","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715107","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"発症前Alzheimer病スペクトラム患者におけるタウ病変の縦断的PET評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"発症前Alzheimer病スペクトラム患者におけるタウ病変の縦断的PET評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-25"},"publish_date":"2017-12-25","publish_status":"0","recid":"72604","relation_version_is_last":true,"title":["発症前Alzheimer病スペクトラム患者におけるタウ病変の縦断的PET評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:37:58.819146+00:00"}