{"created":"2023-05-15T14:53:12.475228+00:00","id":72504,"links":{},"metadata":{"_buckets":{"deposit":"5123a716-754d-465a-a26b-ef3f247145b2"},"_deposit":{"created_by":1,"id":"72504","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72504"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072504","sets":["10:28"]},"author_link":["714028","714017","714018","714025","714035","714033","714034","714031","714038","714041","714022","714026","714029","714027","714037","714021","714016","714020","714036","714039","714032","714030","714040","714019","714023","714024"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-26","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】宇宙放射線に含まれる重粒子線は、生体障害作用が大きく、長期宇宙滞在で危惧される重大なリスク要因である。本研究は、高LET重粒子線（鉄イオン線）の動物個体での遺伝毒性における生物学的効果比（RBE）を明らかにすることを目的とする。【方法】C57BL/6J Jms マウス（雌、8週齢）をX線（200 kVp, 0.50 mm Al+0.50 mm Cu filter, 線量: 0.1, 0.5, 1.0, 3.0, 4.0, 5.0 Gy）もしくは鉄イオン線（500 MeV/nucleon, 200 keV/um, 線量: 0.1, 0.3, 0.5, 1.0, 2.0, 3.0 Gy）で全身照射し、照射後1ヶ月目および2ヶ月目に脾細胞を分離し、染色体標本を作製した。FISH法により、1番（緑）、２番（赤）、３番（黄）染色体を染色し、染色体型の転座、挿入、二動原体、断片の頻度を評価した。【結果および考察】マウスは各群6匹で総計168匹。染色体解析は現在進行中である。照射１ヶ月目の49サンプル（1ヶ月目サンプルの58％）分の結果を集計したところ、X線、鉄イオン線とも、0.5 Gy以上で顕著な染色体異常の増加が認められた。同じ線量（3 Gy）で比較すると、転座（安定型染色体異常）の頻度は、X線の方が鉄イオン線よりも5倍程度高かった。二動原体（不安定型異常）の頻度は、転座に比べかなり低水準であったが、やはりX線の方が鉄イオン線よりも高い傾向にあった。鉄イオン線によるDNA損傷は、X線による損傷に比べて修復されにくいとされている。鉄イオン線によるDNA損傷は、染色体異常として固定されるよりも、細胞死により排除される頻度が高い可能性がある。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会　第60回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"勝部, 孝則"}],"nameIdentifiers":[{"nameIdentifier":"714016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"714017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 薫"}],"nameIdentifiers":[{"nameIdentifier":"714018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮, 康晴"}],"nameIdentifiers":[{"nameIdentifier":"714019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平川, 博一"}],"nameIdentifiers":[{"nameIdentifier":"714020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"劉, 翠華"}],"nameIdentifiers":[{"nameIdentifier":"714021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山, 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孝則","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"714029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"714030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"714031","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"714032","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平川 博一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"714033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"劉 翠華","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"714034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山 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