{"created":"2023-05-15T14:53:11.754812+00:00","id":72493,"links":{},"metadata":{"_buckets":{"deposit":"7d71d459-485c-404c-bc15-3a6d7a0b271f"},"_deposit":{"created_by":1,"id":"72493","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72493"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072493","sets":["10:28"]},"author_link":["713942","713951","713944","713938","713953","713941","713949","713940","713947","713948","713937","713939","713945","713952","713950","713943","713946","713954"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[18F]MNI-659は有用なPDE 10A選択的PET薬剤であり、臨床でハンチントン病等の評価に利用されている。[18F]MNI-659合成は、18F-をTosyl前駆体に直接フッ素化するワンポット反応で行うが、当施設では合成収率がやや低く（約10%）、使用する原料の量にも大きく依存する。そのため、高収量で効率的な標識合成法として[18F]フルオロエチル化による[18F]MNI-659の合成法を検討した。[18F]MNI-659は[18F]フルオロエチルブロマイドとHydroxyl前駆体から[18F]フルオロエチル化反応により合成した。[18F]フルオロエチル化は、ツーポット反応ではあるが、反応液中に不純物が混入しないため、分離精製が容易になり、不純物混入割合がより低くなった。また合成に使用する前駆体の量もワンポット反応に比べて約3分の1に抑えることができ、収率も向上した（25%以上）。[18F]フルオロエチル化により効率的に[18F]MNI-659を合成することができた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古塚, 賢士"}],"nameIdentifiers":[{"nameIdentifier":"713937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"713938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"713939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"713940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 裕輝"}],"nameIdentifiers":[{"nameIdentifier":"713941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井, 誠"}],"nameIdentifiers":[{"nameIdentifier":"713942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤, 正敏"}],"nameIdentifiers":[{"nameIdentifier":"713943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"713944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"713945","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚 賢士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713946","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 若菜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 裕輝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤 正敏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713954","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[18F]MNI-659の効率的な合成法の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[18F]MNI-659の効率的な合成法の検討"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-17"},"publish_date":"2017-10-17","publish_status":"0","recid":"72493","relation_version_is_last":true,"title":["[18F]MNI-659の効率的な合成法の検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:39:13.959550+00:00"}