{"created":"2023-05-15T14:53:11.492442+00:00","id":72489,"links":{},"metadata":{"_buckets":{"deposit":"204cfb74-5544-4840-924e-70f26a5e2599"},"_deposit":{"created_by":1,"id":"72489","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72489"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072489","sets":["10:28"]},"author_link":["713914","713917","713904","713907","713913","713918","713919","713908","713905","713915","713911","713912","713916","713910","713909","713906"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" [18F]MNI-659 はPhosphodiesterase 10A高親和性PET薬剤であり、八ンチントン病等の診断に有用であることが報告されている。我々は臨床応用を目指した[18F]MNI-659の製造法を確立するため、18F標識化合物を合成する最も簡単なトシル原料と18F－との反応条件を検討した。[18F]MNI-659は、18F-をQMAカートリッジに吸着後、K2CO3/K222溶液で溶出し、トシル原料/DMSO溶液と90℃10分間の反応により合成した。66 mM K2CO3を使用した場合は、目的物がほとんど得られなかったが、10 mMで行ったところ目的物の確認ができ、さらに前駆体量を2 mgから4 mgにすることにより収量820±190 MBq、合成時間60分、放射化学純度99%以上、比放射能290±70 GBq/μmolで製造することができ、臨床利用可能な量を得られた。簡便なワンポット法での合成であり、学会GMPに準拠できる[18F]MNI-659製造法を確立できた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武井, 誠"}],"nameIdentifiers":[{"nameIdentifier":"713904","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"713905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 裕輝"}],"nameIdentifiers":[{"nameIdentifier":"713906","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤, 正敏"}],"nameIdentifiers":[{"nameIdentifier":"713907","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"潮見, 聡"}],"nameIdentifiers":[{"nameIdentifier":"713908","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤代, 智也"}],"nameIdentifiers":[{"nameIdentifier":"713909","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚, 賢士"}],"nameIdentifiers":[{"nameIdentifier":"713910","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"713911","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713912","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713913","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 裕輝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713914","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤 正敏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713915","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"潮見 聡","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713916","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤代 智也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713917","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚 賢士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713918","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713919","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"臨床用 [18F]MNI-659製造法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"臨床用 [18F]MNI-659製造法の確立"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-10"},"publish_date":"2017-10-10","publish_status":"0","recid":"72489","relation_version_is_last":true,"title":["臨床用 [18F]MNI-659製造法の確立"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:39:16.569601+00:00"}