{"created":"2023-05-15T14:53:11.361302+00:00","id":72487,"links":{},"metadata":{"_buckets":{"deposit":"1e53ab8b-2e42-4c57-b92a-cd1947c2f5cf"},"_deposit":{"created_by":1,"id":"72487","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72487"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072487","sets":["10:28"]},"author_link":["713893","713886","713882","713884","713892","713889","713880","713885","713887","713891","713881","713890","713883","713888"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"代謝型グルタミン酸受容体は、脳内において各種神経疾患に深く関わっていると言われている。その中でもmGluR2/3 は、統合失調症に対する標的分子として注目されており、mGluR2/3 アゴニストが治療薬として有望視されている。今回我々は、mGluR2 を標的として、キノリン骨格を持つ化合物を合成し、その標識合成及びPET薬剤としての評価を行ったので報告する。標識原料のデスメチル体は、市販試薬から７〜８工程で合成した。[11C]標識体は、 [11C]ヨウ化メチルを標識中間体として合成した。標識体の評価はARG等で行った。[11C]標識合成は、合成時間約３０分、放射化学収率約５０％、放射化学純度９８％以上、と良好な結果であった。ラット脳切片におけるin vitro ARGでは、mGluR2の発現が多い大脳皮質、線条体、海馬に顕著な集積が見られ、さらにmGluR2選択的阻害剤の存在下では、集積の減少が観察された。今後、PETによる評価を行う予定である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"713880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"713881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"713882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"713883","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"713884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"713885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"713886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713888","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713892","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713893","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"新規代謝型グルタミン酸２型受容体選択的PETリガンドの合成と評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規代謝型グルタミン酸２型受容体選択的PETリガンドの合成と評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-10"},"publish_date":"2017-10-10","publish_status":"0","recid":"72487","relation_version_is_last":true,"title":["新規代謝型グルタミン酸２型受容体選択的PETリガンドの合成と評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:39:17.925673+00:00"}