{"created":"2023-05-15T14:53:11.167423+00:00","id":72484,"links":{},"metadata":{"_buckets":{"deposit":"7accbcf3-c0b0-47d7-af81-202ffb02826d"},"_deposit":{"created_by":1,"id":"72484","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72484"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072484","sets":["10:28"]},"author_link":["713846","713844","713852","713853","713848","713849","713845","713851","713847","713850"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳実質細胞の薬剤排出ポンプMRP1の発現や活性の変化は様々な脳疾患で認められていることから、脳実質細胞のMRP1活性を評価することができれば、脳疾患の病態解明に貢献すると期待される。本研究では、BBBを通過後、脳内(実質細胞/血管内皮細胞内)でMRP1基質([11C]S)に変換する[11C]プリン誘導体と[11C]Sを用いて、実質細胞のMRP1活性のインビボ評価を試みた。[11C]プリン誘導体の静脈内投与により、脳内で生成した[11C]SのMrp1欠損マウスにおける排出速度は正常マウスと比較して90％低下した。一方、BBB上のMrp1活性を評価するため、[11C]Sを脳細胞外液に投与した場合、[11C]Sの排出速度はMrp1欠損マウスと正常マウスの間に有意な差は認められなかった。以上、両トレーサを用いることで、Mrp1を介した異物や代謝物の脳からの排出にはBBBではなく脳実質細胞のMrp1が関与していることが明らかとなり、脳実質細胞におけるMrp1活性のインビボ評価の可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡村, 敏充"}],"nameIdentifiers":[{"nameIdentifier":"713844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田, 真希"}],"nameIdentifiers":[{"nameIdentifier":"713845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池, 達矢"}],"nameIdentifiers":[{"nameIdentifier":"713846","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"713847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"713848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村 敏充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713849","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田 真希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713850","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713851","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713853","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"脳実質細胞における薬剤排出ポンプ活性のインビボ評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳実質細胞における薬剤排出ポンプ活性のインビボ評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-10"},"publish_date":"2017-10-10","publish_status":"0","recid":"72484","relation_version_is_last":true,"title":["脳実質細胞における薬剤排出ポンプ活性のインビボ評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:39:19.947659+00:00"}