{"created":"2023-05-15T14:53:11.099537+00:00","id":72483,"links":{},"metadata":{"_buckets":{"deposit":"8477a166-aeb6-45a8-b5e8-be47769e401c"},"_deposit":{"created_by":1,"id":"72483","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72483"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072483","sets":["10:28"]},"author_link":["713822","713831","713840","713826","713835","713820","713836","713824","713839","713829","713830","713818","713833","713837","713841","713834","713832","713823","713843","713825","713819","713827","713828","713842","713838","713821"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"成長ホルモン分泌促進因子受容体 (GHS-R1a)は、摂食亢進や体重増加などエネルギー代謝調節に関連している。GHS-R1aは、主に脳下垂体及び視床下部に存在し、末梢にも広く存在している。数種のGHS-R1a選択的放射性プローブが開発されてきているが、臨床利用されたプローブは報告されていない。我々は、3つの新規GHS-R1a選択的PET用プローブ（[18F]1、[11C]2、[11C]3）を合成し、マウスを用いてインビボ評価を行った。 3つのPET用プローブともインビボ実験に適した収量、比放射能、放射化学的純度で合成できた。プローブ投与60分後では、脳の放射能集積は低く、[11C]3においては膵臓の放射能集積（6.5%ID/g）が高かった。[11C]3用いたPET測定では、膵臓に高い放射能集積を示し、高親和性GHS-R1aリガンドYIL781の前処理により32％の特異的結合を示した。[11C]3は、膵臓でのGHS-R1aの機能を評価できる有用なPET用プローブであると考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"713818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"713819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田, 陽子"}],"nameIdentifiers":[{"nameIdentifier":"713820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"713821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"713822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"713823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"713824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"713825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"713826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 崇之"}],"nameIdentifiers":[{"nameIdentifier":"713827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"713828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"713829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"713830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原 雄祐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 崇之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713843","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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