@misc{oai:repo.qst.go.jp:00072439, author = {Matsumoto, Atsushi and Kono, Hidetoshi and Inoue, Rintaro and Sugiyama, Masaaki and Kato, Daiki and Arimura, Yasuhiro and Kurumizaka, Hitoshi and 松本 淳 and 河野 秀俊}, month = {Sep}, note = {In this study, we built the atomic models of the overlapping dinucleosome in solution by the computational approach based on the experimental data of the small-angle X-ray scattering (SAXS) and the small-angle neutron scattering (SANS). In this computational approach, first, the initial atomic model is deformed by the simulation techniques to generate a lot of deformed atomic models with different conformations. Then, the SAXS and SANS profiles are computed from each deformed atomic model. Finally, these computed profiles are compared with the experimental ones to find the best-fitting atomic models. For the accurate reproduction of the experimental data, it was important to model correctly the histone tails, which are not observed in the X-ray crystal structure., 日本生物物理学会第55回年会}, title = {Model building of overlapping dinucleosome from SAXS and SANS data}, year = {2017} }