{"created":"2023-05-15T14:53:03.480152+00:00","id":72371,"links":{},"metadata":{"_buckets":{"deposit":"28df5970-dd05-49d8-bcdd-1d755d1b64fd"},"_deposit":{"created_by":1,"id":"72371","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72371"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072371","sets":["10:28"]},"author_link":["712877","712887","712886","712885","712876","712879","712883","712888","712882","712889","712890","712878","712880","712881","712874","712884","712875","712873"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-06-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"還元型グルタチオン（GSH）は温度依存的に水中の溶存酸素を還元し、スーパーオキサイド（•O2-）を生成する。44℃でのGSHによる•O2-生成は、ラット胸腺細胞にアポトーシスを誘導することが可能であった。本研究では、汎用されているその他の代表的なチオール（SH）化合物について、その反応性を調べ、酸素の還元による•O2-生成能の有無を評価した。\nヒポキサンチン―キサンチンオキシダーゼ（HX-XO）反応系での•O2-生成、水溶液へのX線照射に起因するヒドロキシルラジカル生成、あるいは3価鉄化合物（K3[Fe(CN)6]）による酸化雰囲気下に0.1 mMのTEMPOLと1 mMのSH化合物とを共存させた時、また0.1 mMのTEMPOLと1 mMのSH化合物を含む水溶液を44℃で加温した時のTEMPOLのEPR信号強度の変化を観察した。\nSH化合物は、いずれの酸化雰囲気下においてもTEMPOLと反応してその常磁性を失わせた。また3価鉄存在下では、NAD(P)H共存下に見られたようなEPRシグナルの回復は生じなかった。すなわちSH化合物は、TEMPOLの酸化によって生じたオキソアンモニウムカチオンと不可逆的に反応すると考えられた。しかし44℃での加温条件下では、GSHのみがTEMPOLの常磁性を消失させた。すなわち酸素からの•O2-生成はGSHのみが可能と考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第70回日本酸化ストレス学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"乳井, 美奈子"}],"nameIdentifiers":[{"nameIdentifier":"712873","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野, 恵美"}],"nameIdentifiers":[{"nameIdentifier":"712874","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根, 絵美子"}],"nameIdentifiers":[{"nameIdentifier":"712875","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 幸大"}],"nameIdentifiers":[{"nameIdentifier":"712876","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上林, 將人"}],"nameIdentifiers":[{"nameIdentifier":"712877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東, 梨佳子"}],"nameIdentifiers":[{"nameIdentifier":"712878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川, 卓志"}],"nameIdentifiers":[{"nameIdentifier":"712879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西, 郁夫"}],"nameIdentifiers":[{"nameIdentifier":"712880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 謙一郎"}],"nameIdentifiers":[{"nameIdentifier":"712881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"乳井 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712883","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 絵美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 幸大","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上林 將人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 梨佳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712888","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712890","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"チオール化合物のスーパーオキサイド生成能の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"チオール化合物のスーパーオキサイド生成能の評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-30"},"publish_date":"2017-06-30","publish_status":"0","recid":"72371","relation_version_is_last":true,"title":["チオール化合物のスーパーオキサイド生成能の評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:40:37.483294+00:00"}