{"created":"2023-05-15T14:53:03.082761+00:00","id":72365,"links":{},"metadata":{"_buckets":{"deposit":"8d1a806f-d8c3-4a8a-8f07-975e46e76729"},"_deposit":{"created_by":1,"id":"72365","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72365"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072365","sets":["10:28"]},"author_link":["712787","712792","712798","712778","712786","712775","712794","712776","712793","712774","712784","712773","712790","712785","712782","712781","712797","712779","712788","712796","712795","712799","712789","712783","712777","712791","712780"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-06-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】陽電子断層撮影（PET）により，Alzheimer 病（AD）\nのアパシー症状と関連するタウタンパク蓄積部位を同定し，\nアパシー・前頭葉回路異常・タウ蓄積の相互関係を明らか\nにする．\n【方法】AD スペクトラム患者17 名に対し，タウ病変プ\nローブ11C-PBB3 によるPET を行い，大脳皮質の各領域\n内のリガンド集積を，小脳に対するSUVR 値として算出\nした．アパシーに関連するヤコブレフ回路障害が前頭葉機\n能異常に関わるものとして，眼窩前頭皮質（OFC）の皮\n質厚と鈎状束（UNC）の拡散パラメータFA 値を，それぞ\nれMRI 構造画像および拡散強調画像から算出した．アパ\nシーはやる気スコア（カットオフ15/16 点）で評価し，ア\nパシー有無群による各定量値の比較と，やる気スコアとの\n相関解析を行い，定量値間の関連性をパス解析で検討した．\n【倫理的配慮】本研究は放射線医学総合研究所医学系研究\n倫理審査委員会の承認を受け，対象者およびその保護者よ\nり文書による同意を得て行われた．\n【結果】アパシー陰性群と比較し，陽性群の前頭葉で\n11C-PBB3 集積の有意な増加を認めた．やる気スコアは前\n頭葉の11C-PBB3 集積と有意な正の相関を認め，OFC の皮\n質厚およびUNC のFA 値と有意な負の相関を認めた．パ\nス解析で前頭葉の11C-PBB3 集積は，直接的およびOFC・\nUNC の異常を介して間接的にやる気スコアと関連するこ\nとが示された．\n【考察】AD において，前頭葉のタウ蓄積が直接的および\nOFC・UNC の変性を介し間接的にアパシー発現に寄与し\nうると考えられた．","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第32会日本老年精神医学会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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