{"created":"2023-05-15T14:53:01.566658+00:00","id":72342,"links":{},"metadata":{"_buckets":{"deposit":"87ceed69-492f-4f8b-a922-266bae287101"},"_deposit":{"created_by":1,"id":"72342","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72342"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072342","sets":["10:28"]},"author_link":["712550","712543","712540","712542","712548","712549","712538","712544","712552","712553","712545","712539","712541","712547","712536","712537","712546","712551"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-05-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Disulfiram (DSF) has been widely used to treat alcoholism for more than half a century and recent studies suggest that DSF may have potential therapeutic effect for several cancers. However, the detail reaction mechanism for the anti-cancer effect of DSF is still not clear. Therefore, the development of [11C]DSF and its in vivo and in vitro studies might be helpful for the understanding of the role of DSF. Here we present the first synthesis of [11C]DSF using [11C]carbon disulfide ([11C]CS2) as a labelling agent. \nMethods: [11C]DSF was synthesized via iodine (I2) oxidation of [11C]diethylcarbamodithioic acid ([11C]DETC), which was prepared by the reaction of [11C]CS2 and diethylamine in acetonitrile (MeCN) at room temperature (r.t.)\nResults: The (decay-corrected isolated) radiochemical yield (RCY) of [11C]DSF was greatly affected by the addition of non-radioactive carbon disulfide (CS2).  In the presence of CS2, RCY was increased up to 22% with low molar radioactivity (0.27 GBq/mol). On the other hand, in the absence of CS2, [11C]DSF was obtained in 0.4% RCY with high molar radioactivity (95 GBq/mol). The radiochemical purities (determined by radio-HPLC analysis of the isolated product) of [11C]DSF were always greater than 98%. The first PET study of [11C]DSF was performed on mice. High uptake of radioactivity in the liver, kidney and gallbladder were observed and the metabolite analysis of mouse serum showed the rapid decomposition of [11C]DSF.\nConclusions: [11C]DSF was successfully synthesized by the reaction of [11C]CS2 with diethylamine followed by I2 oxidation.  Regardless of the molar radioactivity, PET studies of [11C]DSF showed similar uptake in mouse organ and rapid decomposition in serum.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"22nd International symposium on radiopharmaceutical science (ISRS)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishii, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"712536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Joji"}],"nameIdentifiers":[{"nameIdentifier":"712537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding"}],"nameIdentifiers":[{"nameIdentifier":"712538","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru"}],"nameIdentifiers":[{"nameIdentifier":"712539","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanyu, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"712540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Masanao"}],"nameIdentifiers":[{"nameIdentifier":"712541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki"}],"nameIdentifiers":[{"nameIdentifier":"712542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"712543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"712544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 英樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"破入 正行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712553","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Radiosynthesis of [11C]disulfiram and its first in vivo PET studies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiosynthesis of [11C]disulfiram and its first in vivo PET studies"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-25"},"publish_date":"2017-05-25","publish_status":"0","recid":"72342","relation_version_is_last":true,"title":["Radiosynthesis of [11C]disulfiram and its first in vivo PET studies"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:40:57.337503+00:00"}