{"created":"2023-05-15T14:52:54.141766+00:00","id":72229,"links":{},"metadata":{"_buckets":{"deposit":"5605b996-bb2c-4e23-b96b-054007bee986"},"_deposit":{"created_by":1,"id":"72229","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72229"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072229","sets":["10:28"]},"author_link":["711374","711366","711362","711368","711373","711369","711377","711376","711365","711370","711364","711367","711372","711371","711375","711363"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-02-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　　Development　of  radioprotectors is a very important strategy for reducing radiation risk. We have explored compounds that target a zinc-binding site (ZBS) in p53 ,\nand found that 5-chloro-8-quinolinol (5CHQ) has a unique p53-agonistic activity that shifts its transactivation from proapoptotic to protective responses including the enhancement of p21 induction and the suppression of PUMA induction. The dose-reduction factors of 5CHQ in total-body and abdominally irradiated mice were about 1.2 and 1.3, respectively. In this study, in order to investigate the hydroxyl group at the 8-position of the quinolone ring of 5CHO in its radioprotective function, we synthesized 5-chloro-8-methoxyquinoline (5CMQ), whose 8-hydroxyl group is methylated, and comfirmed that it had no antiapoptotic activity against p-53-dependent apoptosis in 10Gy-irradiated MOLT-4 cells when assessed by Annexin V-FITC staining. In addition, immunoblotting analysis revealed that 5CMQ did not alter the expression of P53 and the products of two p53-target genes, p21 and PUMA, These data indicate that the 8-hydroxyl group of 5CHQ is required for its metal-chelating activity in suppressing apoptosis and shifting p-53-transactivation.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"「第1回国際シンポジウム」「Scientific Underpinning for Restoration from a Radiation Disaster（放射線災害からの復興を支える科学的基盤）」","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ujita, Shohei"}],"nameIdentifiers":[{"nameIdentifier":"711362","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mmorita, Akinori"}],"nameIdentifiers":[{"nameIdentifier":"711363","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Shin"}],"nameIdentifiers":[{"nameIdentifier":"711364","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishi, Yurie"}],"nameIdentifiers":[{"nameIdentifier":"711365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuro, Teraoka"}],"nameIdentifiers":[{"nameIdentifier":"711366","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasatani, Megumi"}],"nameIdentifiers":[{"nameIdentifier":"711367","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Bing"}],"nameIdentifiers":[{"nameIdentifier":"711368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Ippei"}],"nameIdentifiers":[{"nameIdentifier":"711369","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"711370","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamakawa, Tomoaki"}],"nameIdentifiers":[{"nameIdentifier":"711371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"711372","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamiya, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"711373","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inaba, Toshiya"}],"nameIdentifiers":[{"nameIdentifier":"711374","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"711375","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"711376","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"711377","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Requirement　of  the 8-hydroxyl group in the 5-chloro-8-quinolinol for its Action as a Radioprotective Agonist","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Requirement　of  the 8-hydroxyl group in the 5-chloro-8-quinolinol for its Action as a Radioprotective Agonist"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-03-22"},"publish_date":"2017-03-22","publish_status":"0","recid":"72229","relation_version_is_last":true,"title":["Requirement　of  the 8-hydroxyl group in the 5-chloro-8-quinolinol for its Action as a Radioprotective Agonist"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:42:17.804558+00:00"}