{"created":"2023-05-15T14:52:51.341613+00:00","id":72165,"links":{},"metadata":{"_buckets":{"deposit":"f4ef917e-0edf-4d4d-904d-f353301d7a5b"},"_deposit":{"created_by":1,"id":"72165","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72165"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072165","sets":["10:28"]},"author_link":["710594","710590","710603","710599","710619","710592","710611","710608","710614","710606","710613","710591","710601","710616","710617","710604","710615","710600","710598","710605","710612","710596","710597","710609","710602","710607","710618","710610","710593","710595"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-10-23","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives:\nFBP is a standard method for quantitative analysis in human neuroreceptor binding\nassay, while OS-EM is used widely in tumor PET imaging. Owing to noise propagation from projection data, especially at high subset number, OS-EM leads to loss of signal to noise (SNR) and quantitative accuracy. A novel reconstruction algorithm DRAMA can suppress the noise propagation by using dynamic relaxation parameter with faster convergence compared to OSEM algorithm. In this study, we compared regional radioactivity concentrations and binding potential (BP) values between FBP, OS-EM and DRAMA to assess the effect of DRAMA algorithm on estimating human nuroreceptor binding. Methods: The PET scanning was carried out with Eminence Sophia(shimadzu corp.) . After 4min pre-injection transmission scan, [11C] FLB457, 90min dynamic PET\nscans were performed with 3D acquisition mode. To compare reconstruction parameter, a phantom scan was done with same scan protocol. Images were reconstructed with FBP, OSEM and DRAMA to assess quantitative accuracy and noise characteristics. Results: To evaluate the SNR, we performed the image quality tests along with NEMA NU-2 2007. Noise of DRAMA was 7% lower than that of FBP. On the other hands, Q10/N10 number of DRAMA was 5.3% higher than that of FBP,similarly, it is 3.5% higher than that of OS-EM. In patient study, the difference of BP by OSEM with\niteration 4, subset 16 compared to FBP was+3.17% at maximum in the caudate, while that of DRAMA was +1.59%. Conclusions:There were no significant differences of BP values in thalamus,frontal\ncortex, temporal cortex and occipital cortex between DRAMA and FBP. Furthermore, noise propagation was not shown in DRAMA in phantom studies. These results indicated that DRAMA could provide similar performance of FBP with the improved SNR, therefore, DRAMA can be a novel standard reconstruction method of neuroreceptor PET studies.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"EANM'13 - Annual Congress of the European Association of Nuclear Medicine","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shiraishi, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"710590","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"710591","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itou, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"710592","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"710593","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakami, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"710594","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Takamasa"}],"nameIdentifiers":[{"nameIdentifier":"710595","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanimoto, Katsuyuki"}],"nameIdentifiers":[{"nameIdentifier":"710596","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohashi, Seiya"}],"nameIdentifiers":[{"nameIdentifier":"710597","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toubaru, Sachiko"}],"nameIdentifiers":[{"nameIdentifier":"710598","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshikawa, Kyosan"}],"nameIdentifiers":[{"nameIdentifier":"710599","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Harumasa"}],"nameIdentifiers":[{"nameIdentifier":"710600","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"710601","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"710602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"710603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibayama, Kouichi"}],"nameIdentifiers":[{"nameIdentifier":"710604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白石 貴博","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 博","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 徳幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩上 英樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 貴雅","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷本 克之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大橋 靖也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"桃原 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川 京燦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 比呂志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柴山 晃一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710619","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"The effect of DRAMA on estimating human nuro-receptor binding potential with PET","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The effect of DRAMA on estimating human nuro-receptor binding potential with PET"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-03-03"},"publish_date":"2017-03-03","publish_status":"0","recid":"72165","relation_version_is_last":true,"title":["The effect of DRAMA on estimating human nuro-receptor binding potential with PET"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:43:01.334156+00:00"}