{"created":"2023-05-15T14:52:48.692812+00:00","id":72104,"links":{},"metadata":{"_buckets":{"deposit":"66cb9063-2414-446c-be5d-77e50c5805c0"},"_deposit":{"created_by":1,"id":"72104","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72104"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072104","sets":["10:28"]},"author_link":["710065","710076","710068","710078","710070","710067","710077","710066","710074","710064","710063","710072","710073","710069","710075","710079","710071"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-08-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Dopamine synthesis rate, one of the presynaptic functions of the central dopaminergic\nsystem, can be measured by positron emission tomography (PET) measurement with L-[β-11C]DOPA\n[1]. The radiolabeled O-methyl metabolite of L-[β-11C]DOPA in peripheral organ, L-[β-11\nC]O-methyl-DOPA (L-[β-11C]OMD), suggested to penetrate the blood-brain barrier (BBB). Thus, L-[β-\n11C]OMD may affect tissue radioactivity measured by PET and the endogenous dopamine synthesis rate\nestimated by kinetic analyses. However, the influence of L-[β-11C]OMD in the living tissue for the\nkinetic analyses has not been investigated in detail. In the present study, to evaluate the influence of\nL-[β-11C]OMD on the tissue time-activity curve (TAC) with L-[β-11C]DOPA PET, the metabolite\ncorrection was applied to tissue TACs acquired from healthy volunteers.\nMethods: The metabolite correction method proposed by Kumakura et al. in [18F]FDOPA PET study\n[2] was employed. In this method, component for O-methyl metabolite in the tissue TAC is estimated by\ncompartmental analysis with two kinds of arterial input function for L-[β-11C]DOPA and L-[β-11\nC]OMD, and TAC in occipital cortex as a reference region with no irreversible binding. TAC in each\nbrain region for L-[β-11C]DOPA PET studies with ten healthy volunteers [1] was corrected by using the\nestimated L-[β-11C]OMD TAC. This method assumes the distribution of O-methyl metabolite is\nuniform around the brain [3].\nThe endogenous dopamine synthesis rate (Ki) was estimated by Gjedde-Patlak plot analysis with the\narterial input function and the metabolite-corrected TAC. The Ki was also estimated from the\nnon-corrected TAC. For comparison to conventional analysis, relative influx constant (kref) was also\nestimated by Gjedde-Patlak plot analysis using TAC in occipital cortex, regarded as reference tissue\ninput function. Data of 29 – 64 min and 29 – 89 min were used for linear regression in Gjedde-Patlak\nplot analysis.\nResults: Calculated OMD component had only a marginal effect on tissue TAC (fraction of area under\ncurve (AUC) of L-[β-11C]OMD TAC in putaminal TAC: 9.4 ± 2.1 %). Ki with no metabolite corrected\nTAC correlated significantly to Ki with the metabolite correction (p < 0.001, r = 0.99 (29 – 64 min), p <\n0.001, r = 0.99 (29 – 89 min)), and Ki were overestimated in all brain regions with no metabolite\ncorrection, see Figure A. kref also correlated to Ki with the metabolite correction, as shown in Figure B\n(p < 0.001, r = 0.99 (29 – 64 min), p < 0.001, r = 0.99 (29 – 89 min)).\nConclusion: The results suggest that the influence of the O-methyl metabolite L-[β-11C]OMD to tissue\nTAC and kinetic parameters in L-[β-11C]DOPA PET is marginal. This finding is accounted for by low\nfraction of L-[β-11C]OMD in plasma in case of L-[β-11C]DOPA, in contrast with high fraction of\nO-methyl metabolite for [18F]FDOPA. The results also suggest the net endogenous dopamine synthesis\nrate can be determined without the metabolite correction in case of L-[β-11C]DOPA, not same as [18\nF]FDOPA.\nReference\n[1] Ito H., et al., 2006, Nucl. Med. Commun. 27, 723-731\n[2] Kumakura Y., et al., 2005, J. Cereb. Blood Flow Metab. 25, 807-819\n[3] Doudet D.J., et al., 1991, J. Cereb. Blood Flow Metab. 11, 726-734\nNote - image will be printed in black & white","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The Ninth International Symposium on Functional Neuroreceptor Mapping of the Living Brain","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsubara, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"710063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"710064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"710065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Maki"}],"nameIdentifiers":[{"nameIdentifier":"710066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanobu, Ibaraki"}],"nameIdentifiers":[{"nameIdentifier":"710067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"710068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"710069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"710070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kinoshita, Toshibumi"}],"nameIdentifiers":[{"nameIdentifier":"710071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松原 佳亮","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田 真希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"茨木 正信","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 和浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口 博司","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710079","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Correction for Radiolabeled O-Methyl Metabolite in Human Brain","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Correction for Radiolabeled O-Methyl Metabolite in Human Brain"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-22"},"publish_date":"2016-12-22","publish_status":"0","recid":"72104","relation_version_is_last":true,"title":["Correction for Radiolabeled O-Methyl Metabolite in Human Brain"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:43:46.283904+00:00"}