{"created":"2023-05-15T14:52:48.605250+00:00","id":72102,"links":{},"metadata":{"_buckets":{"deposit":"e976de96-4408-45e1-8e01-b0becc66d067"},"_deposit":{"created_by":1,"id":"72102","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72102"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072102","sets":["10:28"]},"author_link":["710046","710041","710047","710045","710043","710040","710048","710044","710049","710038","710042","710039"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-11-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腫瘍イメージング剤である[11C]コリンは広く臨床利用されている。コリン及び原料であるジメチルアミノエタノール（DMAE）はUV吸収を持たないため、UV検出器を用いての[11C]コリン比放射能及びDMAE混入量測定が困難である。本研究では、UV吸収を持たない化合物でも測定可能なコロナ荷電化粒子検出器（CAD）を用いて、[11C]コリンの比放射能測定及びDMAE混入量測定を検討した。分析条件として陽イオンカラムを使用し、CADに適した移動相を用いて検討を行った。結果コリン及びDMAEを10分以内で測定することができ、高い再現性（5%以内）、優れた直線性（R2=0.999）で、0.2 μg/mLまでのコリン及び0.5μg/mLまでのDMAEを測定することができた。　放医研で製造した[11C]コリン注射液では、比放射能が61GBq/μmol（コリン濃度0.7μg/mL）であり、DMAE混入量は24μg/mLであった。本分析法は[11C]コリン比放射能及びDMAE混入量を迅速かつ高感度で測定することができ、分析法バリデーションが可能であるため学会GMPに対応できる品質検査法であると考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第56回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古塚, 賢士"}],"nameIdentifiers":[{"nameIdentifier":"710038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"710039","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 裕輝"}],"nameIdentifiers":[{"nameIdentifier":"710040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"狩谷, 香"}],"nameIdentifiers":[{"nameIdentifier":"710041","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"710042","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"710043","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚 賢士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710044","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710045","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 裕輝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710046","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"狩谷 香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710047","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710048","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710049","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"学会GMPに対応できるコロナ荷電化粒子検出器を用いた[11C]コリンの比放射能測定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"学会GMPに対応できるコロナ荷電化粒子検出器を用いた[11C]コリンの比放射能測定"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-22"},"publish_date":"2016-12-22","publish_status":"0","recid":"72102","relation_version_is_last":true,"title":["学会GMPに対応できるコロナ荷電化粒子検出器を用いた[11C]コリンの比放射能測定"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:43:47.643953+00:00"}