{"created":"2023-05-15T14:52:48.562075+00:00","id":72101,"links":{},"metadata":{"_buckets":{"deposit":"127dd886-70bd-4773-bbdc-44805b896a22"},"_deposit":{"created_by":1,"id":"72101","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72101"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072101","sets":["10:28"]},"author_link":["710021","710034","710032","710033","710036","710028","710020","710023","710025","710037","710024","710026","710027","710022","710029","710030","710031","710035"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-11-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"モノアシルグリセロールリパーゼ(MAGL)は、脳内カンナビノイド受容体の活性を制御する酵素である。本研究では新規MAGLイメージング剤を開発するため、強いMAGL阻害活性を有するカルバメート構造を持つSAR127303 (1)及びそのウレア誘導体2を11Cによって標識し、ラット等による評価を行った。[11C]1及び[11C]2は、それぞれ[11C]COCl2とアルコールもしくはアミンを反応させて対称[11C]炭酸エステル、[11C]ウレアを得た後、アミンと反応させることによって合成した。[11C]1及び[11C]2は、合成時間33-38分、放射化学収率3-7% ([11C]CO2捕取からEOS)、比放射能＞37GBq/μmolで得られた。ラットを用いたPET撮像を行ったところ、[11C]2は脳内への取り込みが低かったのに対し、[11C]1は、MAGLが高い活性を示す大脳皮質、線条体、海馬及び小脳などにおいて顕著な放射能集積が見られた。また、これらの脳内集積は、MAGLの特異的な阻害剤であるKML29の前投与によって、著しく減少された。よって、[11C]1は脳内MAGLの新規PETイメージング剤として有用であることが明らかとなった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第56回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"710020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"710021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"710022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"710023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"710024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"710025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"710026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"710027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"710028","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 若菜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原 雄祐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710031","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710032","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710037","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"モノアシルグリセロールリパーゼをターゲットとする新規PETイメージング剤の合成と評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"モノアシルグリセロールリパーゼをターゲットとする新規PETイメージング剤の合成と評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-22"},"publish_date":"2016-12-22","publish_status":"0","recid":"72101","relation_version_is_last":true,"title":["モノアシルグリセロールリパーゼをターゲットとする新規PETイメージング剤の合成と評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:43:48.326253+00:00"}