{"created":"2023-05-15T14:52:48.518865+00:00","id":72100,"links":{},"metadata":{"_buckets":{"deposit":"3c76b197-6e5b-4c72-b341-5e645b485c69"},"_deposit":{"created_by":1,"id":"72100","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72100"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072100","sets":["10:28"]},"author_link":["710011","710006","710008","710003","710010","710005","710004","710002","710007","710009","710015","710016","710017","710019","710013","710014","710018","710012"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-11-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Monoacylglycerol lipase(MAGL)はendocannabinoidの2-arachdonoylglycerolを分解する酵素であり、また組織内脂肪の分解にも関与している。MAGLの高発現は褐色脂肪の活性化に関連し、効率的なカロリーの消費、そして抗肥満効果につながると考えられる。褐色脂肪及びその活性化を可視化するため、今回MAGLの阻害剤であるPADを標識し、PAD の新規PET用プローブとしての可能性を検討した。同一前駆体に、それぞれ[11C]CH3I、[18F]FEtBrおよび[18F]FPrBrを用いて収率よく標識し、[11C]PAD、[18F]FEtPADおよび[18F]FPrPADを合成した。[11C]PADの体内分布では、腎、肝、褐色脂肪が時間経過につれ高い放射能集積を示した。またMAGL阻害剤の前投与により褐色脂肪等に集積の阻害を受けた。褐色脂肪への放射能の取り込みは、MAGLの発現によるものと考えられた。二つの[18F]標識体は[11C]PADと同様の初期の取り込みを示したが、経時変化・代謝速度に差が認められた。これらのことから、今回標識した新規PETプローブは褐色脂肪のイメージングに有用であると示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第56回日本核医学会学術総会にポスター発表の為","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"710002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"710003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"710004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"710005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"710006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"710007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"710008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"710009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"710010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 若菜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原 雄祐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710019","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"褐色脂肪におけるMonoacylglycerol lipaseを標的としたPETプローブの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"褐色脂肪におけるMonoacylglycerol lipaseを標的としたPETプローブの開発"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-22"},"publish_date":"2016-12-22","publish_status":"0","recid":"72100","relation_version_is_last":true,"title":["褐色脂肪におけるMonoacylglycerol lipaseを標的としたPETプローブの開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:43:49.000909+00:00"}