{"created":"2023-05-15T14:52:48.430504+00:00","id":72098,"links":{},"metadata":{"_buckets":{"deposit":"f5ad82ac-00d4-4a92-8eb6-18cdd49440a2"},"_deposit":{"created_by":1,"id":"72098","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72098"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072098","sets":["10:28"]},"author_link":["709978","709973","709981","709985","709967","709977","709982","709976","709966","709980","709968","709970","709969","709971","709984","709972","709983","709979","709975","709974"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-11-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"カンナビノイド受容体1(CB1)は脳や末梢組織に広く分布しており、特に褐色脂肪組織（BAT）において高発現が確認されている。近年、CB1は、BATにおける熱生産を調節していることが分かってきており、抗肥満薬開発の標的分子として注目されている。PSNCBAM-1は、CB1のアロステリック阻害剤として開発され、動物実験において抗肥満効果が報告されている。本研究ではCB1-PETプローブの候補化合物として、非対称ウレア構造を持つPSNCBAM-1の誘導体PSNDM, PSNPを選択し、11C標識を行った。[11C]PSNDM及び[11C]PSNPは、p-置換アニリンを低温下にて11COCl2と反応させた後、ピリジン誘導体を加えることにより合成した。[11C]PSNDMは、合成時間35分、収率20%（EOB）で得ることができ、[11C]PSNPは合成時間40分、収率21%で得ることができた。いずれの化合物も、放射化学的純度98％以上で得られており、動物評価に適した品質であった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第56回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下田, 陽子"}],"nameIdentifiers":[{"nameIdentifier":"709966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"709967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"709968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"709969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"709970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"709971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"709972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"709973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"709974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"709975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 若菜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 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