{"created":"2023-05-15T14:52:46.268798+00:00","id":72049,"links":{},"metadata":{"_buckets":{"deposit":"e34f22a1-3ba9-449e-942b-487cf0ec0d3c"},"_deposit":{"created_by":1,"id":"72049","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72049"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072049","sets":["10:28"]},"author_link":["709608","709606","709607","709605","709603","709604","709609"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-07-02","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"放射線生物学において臨床でも基礎実験においても生物学的効果解析の際に頻用されているlinear quadratic model（LQモデル）における生物学的パラメータであるα、βの値のLET依存性を調べるため、NHEJ修復関連DNA-PKの阻害剤を投与したヒト皮膚繊維芽細胞NHDFを群馬大学重粒子線照射施設と量研機構高崎TIARAの炭素線で照射し、コロニー形成法で感受性を調べた。NU7026(-)において、NHDF細胞から得られた細胞生存率曲線はLET依存的に急峻になり、RBEはLET依存的に増加した。α値およびβ値はLETの増加と共に大きくなった。NU7026(+)においても、細胞生存率曲線はLET依存的に急峻になり、RBEはLET依存的に増加した。しかしながら、α値はLETに非依存的であった一方で、β値はNU7026(-)と大きな違いは認められなかった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第22回癌治療増感研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 由香里"}],"nameIdentifiers":[{"nameIdentifier":"709603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 昭久"}],"nameIdentifiers":[{"nameIdentifier":"709604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"709605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"八高, 知子"}],"nameIdentifiers":[{"nameIdentifier":"709606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"舟山, 知夫"}],"nameIdentifiers":[{"nameIdentifier":"709607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野, 隆史"}],"nameIdentifiers":[{"nameIdentifier":"709608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"舟山 知夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709609","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ヒト正常皮膚細胞における生物学的パラメータの LET 依存性に及ぼす NHEJ 修復の寄与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト正常皮膚細胞における生物学的パラメータの LET 依存性に及ぼす NHEJ 修復の寄与"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-11-01"},"publish_date":"2016-11-01","publish_status":"0","recid":"72049","relation_version_is_last":true,"title":["ヒト正常皮膚細胞における生物学的パラメータの LET 依存性に及ぼす NHEJ 修復の寄与"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:44:24.686104+00:00"}