{"created":"2023-05-15T14:52:44.475269+00:00","id":72008,"links":{},"metadata":{"_buckets":{"deposit":"887c93ec-1bf8-4380-a4a7-20feaced1b6b"},"_deposit":{"created_by":1,"id":"72008","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72008"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072008","sets":["10:28"]},"author_link":["709283","709274","709272","709276","709281","709277","709282","709271","709269","709279","709270","709273","709268","709278","709280","709275","709285","709284"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-08-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2,2-ジフェニル-1-ピクリルヒドラジル(DPPH)ラジカルは、抗酸化物質による還元や活性酸素種による酸化を受け、その溶液の紫色が消失することが知られている。しかし、DPPHラジカルは水にまったく溶けないため水溶液中で用いるためにはメタノールなどの共溶媒が必要である。我々は最近、β-シクロデキストリン(β-CD)によりDPPHラジカルを水溶化することに成功し、高濃度(0.1 M)の緩衝液中における水溶性抗酸化物質の活性評価を可能にした(Chem Commun 2015; 51: 8311)。本研究では、β-CDで水溶化したDPPHラジカル (DPPHラジカル/β-CD)に種々の放射線を照射し、発生する活性酸素種との反応について検討した。\n　DPPHラジカル/β-CD水溶液にX線(1〜20 Gy, 200 kV, 20 mA, 0.5mm Cu + 0.5mm Al, 1.72 Gy/min)を照射すると、DPPHラジカルに由来する527 nmの吸収が線量依存的に減少した。527 nmの吸光度を線量に対してプロットすると良好な直線関係が得られた。炭素イオン線(1〜20 Gy, 290 MeV/nucleon, 13.3 keV/µm)を照射した場合にも同様の結果が得られた。パルスラジオリシス法(49.4 Gy)により反応を追跡した結果、放射線で発生したOHラジカルは、まずβ-CDと反応し、その結果生成したβ-CD由来のラジカル種とDPPHラジカルが反応していることが分かった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第69回日本酸化ストレス学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中西, 郁夫"}],"nameIdentifiers":[{"nameIdentifier":"709268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川, 卓志"}],"nameIdentifiers":[{"nameIdentifier":"709269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山下, 真一"}],"nameIdentifiers":[{"nameIdentifier":"709270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上林, 將人"}],"nameIdentifiers":[{"nameIdentifier":"709271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 幸大"}],"nameIdentifiers":[{"nameIdentifier":"709272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野, 恵美"}],"nameIdentifiers":[{"nameIdentifier":"709273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根, 絵美子"}],"nameIdentifiers":[{"nameIdentifier":"709274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤, 俊彦"}],"nameIdentifiers":[{"nameIdentifier":"709275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 謙一郎"}],"nameIdentifiers":[{"nameIdentifier":"709276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山下 真一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上林 將人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 幸大","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 絵美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤 俊彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709285","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"β-シクロデキストリンで水溶化した2,2-ジフェニル-1-ピクリルヒドラジルラジカル(DPPH・)への放射線照射","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"β-シクロデキストリンで水溶化した2,2-ジフェニル-1-ピクリルヒドラジルラジカル(DPPH・)への放射線照射"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-09-01"},"publish_date":"2016-09-01","publish_status":"0","recid":"72008","relation_version_is_last":true,"title":["β-シクロデキストリンで水溶化した2,2-ジフェニル-1-ピクリルヒドラジルラジカル(DPPH・)への放射線照射"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:44:51.511092+00:00"}