{"created":"2023-05-15T14:52:39.083847+00:00","id":71885,"links":{},"metadata":{"_buckets":{"deposit":"db6e9062-60db-4ca2-859e-3fd15642e34b"},"_deposit":{"created_by":1,"id":"71885","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71885"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071885","sets":["10:28"]},"author_link":["707972","707962","707961","707964","707970","707967","707963","707965","707966","707969","707968","707971"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: Simple vascular function measurements are desirable for atherosclerosis risk assessments. Recently, we developed a novel modality of automated oscillometric method to measure a brachial artery’s vascular elastic modulus (VE) and reported that VE is uninfluenced by blood pressure. Galectin-3 (Gal-3) expressed in endothelial cells regulates vascular fibrosis and is a molecular determinant of vascular stiffness. \nHypothesis: We aimed to clarify whether VE selectively correlates with marker of vascular stiffness in chronic kidney disease (CKD). \nMethods: 12 moderate-to-severe CKD pts (mean eGFR 25.9±23.5 mL/min/1.73m2) and 15 controls were studied. Rest VE in brachial artery was measured by new automated oscillometric detector. VE was defined as follows [VE =ΔPressure/ (100XΔarea/Area) mmHg/%]. Using ultrasound, the brachial artery diameter at rest and during reactive hyperemia [flow mediated dilatation (FMD) with endothelial-dependent dilatation] was measured. Gal-3 and interleukin-6 (IL-6), a representative inflammatory marker, were measured by enzyme-linked immune assay.\nResults: CKD had lower FMD (4.86±3.37 vs 9.05±2.98 %, P=0.003) and had attenuated VE than control (1.08±0.26 vs 0.83±0.17 mmHg/%, P=0.002). CKD had higher IL-6 (0.67±0.29 vs 0.29±0.33 pg/mL, P=0.003) and higher Gal-3 (20.0±12.4 vs. 5.84±2.83 pg/mL, P<0.001). VE was negatively correlated with %FMD (r=-0.46, P=0.015) and correlated with Gal-3 (r=0.40, P=0.036) but not in IL-6 (r=0.21, P=0.28).\nConclusions: Attenuated vascular elasticity detected by this novel approach closely correlated with increase in Gal-3 and reduced FMD in CKD. This may indicate that the attenuated vascular elasticity selectively reflects vascular fibrosis as evidenced by Gal-3 and subsequent endothelial responses to vascular stiffness. Thus, this oscillometric measurement may be useful for detecting vascular fibrosis information and dysfunction in endothelium level.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"American Heart Association scientific session 2015 ","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshinaga, Keiichito"}],"nameIdentifiers":[{"nameIdentifier":"707961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomiyama, Yuuki"}],"nameIdentifiers":[{"nameIdentifier":"707962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujii, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"707963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishio, Saori"}],"nameIdentifiers":[{"nameIdentifier":"707964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ochi, Noriki"}],"nameIdentifiers":[{"nameIdentifier":"707965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katoh, Chietsugu"}],"nameIdentifiers":[{"nameIdentifier":"707966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Mamiko"}],"nameIdentifiers":[{"nameIdentifier":"707967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishida, Mutumi"}],"nameIdentifiers":[{"nameIdentifier":"707968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeuchi, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"707969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"M., Ito Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"707970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamaki, Nagara"}],"nameIdentifiers":[{"nameIdentifier":"707971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉永 恵一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707972","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Vascular Elasticity Measured by Novel Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometry Correlates With Molecular Determinant of Vascular Fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Vascular Elasticity Measured by Novel Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometry Correlates With Molecular Determinant of Vascular Fibrosis"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-07"},"publish_date":"2015-12-07","publish_status":"0","recid":"71885","relation_version_is_last":true,"title":["Vascular Elasticity Measured by Novel Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometry Correlates With Molecular Determinant of Vascular Fibrosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:46:18.129445+00:00"}