{"created":"2023-05-15T14:52:38.127987+00:00","id":71863,"links":{},"metadata":{"_buckets":{"deposit":"f3d355b1-8cda-4826-bddb-0bef119200d8"},"_deposit":{"created_by":1,"id":"71863","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71863"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071863","sets":["10:28"]},"author_link":["707629","707635","707628","707634","707637","707638","707636","707639","707640","707641","707633","707630","707632","707631"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"統合失調症の「グルタミン酸仮説」に基づく代謝型グルタミン酸２／３型受容体（mGlu2/3）受容体アゴニストの作用機序より、その新規統合失調症治療薬としての可能性が示唆されている。　今回我々は、脳内におけるmGluR2の画像化を目的として、ヤンセン社が発表したmGlu2アゴニストである3-cyano-dihydropyrimidine誘導体を選択し、11Cによる標識合成を行ったので報告する。\n標準物質のメトキシ体は、論文記載の方法に従って市販試薬より合成した。また、標識原料となるデスメチル体は、三臭化ホウ素を用いた脱メチル化反応により合成した。11C標識体は、標識中間体として[11C]ヨウ化メチルを用いて、合成時間約３０分、放射化学収率約６〜７０％、放射化学純度９８％以上で合成する事が出来た。また得られた標識体の比放射能は約74GBq/umolであり、室温下９０分以上安定であった。今後は、本リガンドを用いてPET及びARGなどの評価を行う予定である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"707628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"707629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田, 陽子"}],"nameIdentifiers":[{"nameIdentifier":"707630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"707631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"707632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"707633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"707634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707641","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"新規mGlu2受容体選択的PETリガンドの標識合成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規mGlu2受容体選択的PETリガンドの標識合成"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-24"},"publish_date":"2015-11-24","publish_status":"0","recid":"71863","relation_version_is_last":true,"title":["新規mGlu2受容体選択的PETリガンドの標識合成"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:46:31.681974+00:00"}