{"created":"2023-05-15T14:52:37.993259+00:00","id":71860,"links":{},"metadata":{"_buckets":{"deposit":"cfa12e01-9036-426f-8a9d-224483597730"},"_deposit":{"created_by":1,"id":"71860","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71860"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071860","sets":["10:28"]},"author_link":["707587","707588","707581","707582","707589","707579","707580","707584","707578","707586","707590","707583","707591","707585"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"褐色脂肪細胞はミトコンドリアに富み、内膜に発現するUCP1は基質酸化のエネルギーを熱として放散する機能をもつため、これらを活性化することが抗肥満効果を高めるといわれている。今回、2型糖尿病モデルラット（ZDF-Leprfa/CrlCrlj）を用いTSPOのPET用プローブ[18F]FEDACを用いて糖尿病ラットの褐色脂肪（BAT）をイメージングし、知見を得ることを目的とした。ZDFラット（FattyおよびLean）にアドレナリン受容体作動薬（CL316243；CL）もしくは生理食塩液を14日間持続投与し、[18F]FEDAC-PET、放射能濃度測定、ウエスタンブロッティング（WB）、組織化学染色等を行った。PETを用いた肩甲骨間および傍脊椎BATへの放射能取り込みは、CLの投与により明らかに上昇し、Fattyにおける肩甲骨間BATのSUV30minは6.5～8.5とLeanのCL群と同レベルを示した。WBによりFatty およびLeanのCL群におけるTSPOおよびUCP1の発現の増加が確認された。TSPOをターゲットとした[18F]FEDAC-PETは褐色脂肪のイメージングに有用であると示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"707578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"707579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"707580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"707581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"707582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井, 誠"}],"nameIdentifiers":[{"nameIdentifier":"707583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"707584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707587","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707588","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707590","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707591","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"糖尿病モデルZDFラットにおける褐色脂肪の[18F]FEDAC-PETイメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病モデルZDFラットにおける褐色脂肪の[18F]FEDAC-PETイメージング"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-19"},"publish_date":"2015-11-19","publish_status":"0","recid":"71860","relation_version_is_last":true,"title":["糖尿病モデルZDFラットにおける褐色脂肪の[18F]FEDAC-PETイメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:46:33.090448+00:00"}