{"created":"2023-05-15T14:52:37.595441+00:00","id":71851,"links":{},"metadata":{"_buckets":{"deposit":"59eb0225-75d4-4893-9193-759ba5eb6fc6"},"_deposit":{"created_by":1,"id":"71851","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71851"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071851","sets":["10:28"]},"author_link":["707475","707474","707472","707480","707470","707471","707477","707473","707479","707481","707478","707476"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】生体内で代謝安定なα-メチルアミノ酸は、アミノ酸輸送亢進を標的とした腫瘍イメージングへの利用が期待される。側鎖にエチル基を有するIsovaline (Iva) は、腫瘍に高集積することが知られることから、[11C]Ivaの標識合成法を確立し、PETプローブとしての可能性を評価した。【方法】α-アミノ酸エステルのSchiff塩基誘導体を種々の塩基存在下、[11C]ヨウ化メチルを用いてメチル化した。[11C]Ivaのin vitro細胞取り込みをヒト小細胞性肺がん由来細胞SYを用いて評価した。[11C]Iva をSY皮下移植マウスに静脈内投与し、体内分布を評価した。【結果】11C-メチル化は、塩基にKOtBuを用いることで最も高収率に進行し、脱保護を経て[11C]Ivaを得た。[11C]IvaはNa+非依存的にSY細胞に取り込まれ、その取り込みはL型アミノ酸トランスポーターの阻害剤添加により阻害された。[11C]Iva-PETは腫瘍を明瞭に描出し、[11C]Ivaの膵臓と腎臓・膀胱を除く正常組織への集積は低値であった。【結論】[11C]Ivaが腫瘍PETイメージングに有用である可能性が示された。 ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 千恵"}],"nameIdentifiers":[{"nameIdentifier":"707470","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"707471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 孝一"}],"nameIdentifiers":[{"nameIdentifier":"707472","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤, 仁美"}],"nameIdentifiers":[{"nameIdentifier":"707473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"707474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"間賀田 泰寛"}],"nameIdentifiers":[{"nameIdentifier":"707475","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"707476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 千恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤 仁美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707481","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"α-[11C]メチルアミノ酸を母体とした腫瘍PETプローブの開発 ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"α-[11C]メチルアミノ酸を母体とした腫瘍PETプローブの開発 "}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-11"},"publish_date":"2015-11-11","publish_status":"0","recid":"71851","relation_version_is_last":true,"title":["α-[11C]メチルアミノ酸を母体とした腫瘍PETプローブの開発 "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:46:39.357012+00:00"}