{"created":"2023-05-15T14:52:37.552614+00:00","id":71850,"links":{},"metadata":{"_buckets":{"deposit":"51513482-e93e-429f-8810-678f2a8f3f2f"},"_deposit":{"created_by":1,"id":"71850","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71850"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071850","sets":["10:28"]},"author_link":["707465","707456","707457","707455","707469","707462","707463","707467","707460","707468","707453","707464","707461","707466","707459","707454","707458"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は、患者がん細胞を培養する新技術Cancer Tissue Originated Spheroid(CTOS)を用いた検討に基づき、HER3をがんの難治性に係る因子の一つと考え、HER3のPETイメージングの可能性について、Zr-89 標識抗HER3抗体(Mab#58)を用いて検討してきた。これまでに報告したHER3過剰発現がん細胞株移植腫瘍および大腸癌由来のCTOS C45の陽性描出に加え、今回は、肺がん由来のCTOS OMLC-5移植腫瘍のPET撮像を行い、これまでの結果とあわせ、Zr-89標識 Mab#58により、患者がんの性質を反映し、かつ、HER3の増殖への関与が確認されているCTOSの移植腫瘍モデルにおいて、HER3の特異的なPETイメージングが可能なことを示した。以上より、Zr-89標識抗HER3抗体によるPETイメージングは、HER3標的するin vivoイメージング法として有望と考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"元, 清華"}],"nameIdentifiers":[{"nameIdentifier":"707453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"707454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"707455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永津, 弘太郎"}],"nameIdentifiers":[{"nameIdentifier":"707456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"707457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上, 正宏"}],"nameIdentifiers":[{"nameIdentifier":"707458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"益子, 高"}],"nameIdentifiers":[{"nameIdentifier":"707459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"707460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"707461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林, 康久"}],"nameIdentifiers":[{"nameIdentifier":"707462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"元 清華","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永津 弘太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707468","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林 康久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707469","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"HER3を標的とするZr-89 標識抗体によるPETイメージング：CTOS移植腫瘍での検討 ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HER3を標的とするZr-89 標識抗体によるPETイメージング：CTOS移植腫瘍での検討 "}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-11"},"publish_date":"2015-11-11","publish_status":"0","recid":"71850","relation_version_is_last":true,"title":["HER3を標的とするZr-89 標識抗体によるPETイメージング：CTOS移植腫瘍での検討 "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:46:40.029831+00:00"}