{"created":"2023-05-15T14:52:36.848821+00:00","id":71834,"links":{},"metadata":{"_buckets":{"deposit":"31547d5a-7409-4697-a567-67bc1e5aa50b"},"_deposit":{"created_by":1,"id":"71834","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71834"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071834","sets":["10:28"]},"author_link":["707276","707272","707270","707267","707269","707271","707278","707265","707264","707266","707263","707275","707273","707274","707268","707277"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-09-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Exposure to either ionizing radiation (IR) or psychological stress (PS) could cause detrimental effects on humans. A recent study showed that chronic restraint induced PS (CRIPS) could attenuate Trp53 functions and increase radiocarcinogenesis in Trp53-heterozygous mice, having a big impact on the academic and a sensational effect on the public, especially the residents living in the radioactively contaminated areas. To elucidate possible modification effects from CRIPS on radiation-induced health consequences in Trp53 wild type (Trp53wt) animals, a series of investigation with multidisciplinary analyses was done. We demonstrate here the changes in frequency of chromosomal aberrations (CAs) in splenocytes. Five-week-old male Trp53wt C57BL/6J mice were restrained 6 hours per day for consecutive 28 days, and total-body irradiation (TBI) at a dose of 4 Gy was given on the 8th day. Metaphase chromosome spreads prepared from splenocytes at the end of the 28-day restraint regimen were painted with the fluorescence in situ hybridization (FISH) probes for chromosomes 1 (green), 2 (red) and 3 (yellow). Results showed that CRIPS alone did not induce CAs, while TBI\ncaused significant increase of CAs, mostly stable types (translocations and insertions). Intriguingly, the stable-type CAs appeared at a little high frequency in mice exposed to TBI plus CRIPS than those in mice exposed to TBI alone. Whereas, the frequency of unstable-type CAs (dicentrics and fragments) was not differ between these experimental groups (TBI+CRIPS vs. TBI). CRIPS does not seem to have a significant impact on initiation of radiocarcinogenesis of splenocytes because clastogenic effect of TBI was not enhanced by CRIPS. Further investigations elucidating possible modification effects from CRIPS on promotion and/or progression of radiocarcinogenesis of Trp53wt mice must be needed.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"2015 RRS (Radiation Research Society)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"勝部, 孝則"}],"nameIdentifiers":[{"nameIdentifier":"707263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"707264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"707265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ninomiya, Yasuharu"}],"nameIdentifiers":[{"nameIdentifier":"707266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"707267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"劉強"}],"nameIdentifiers":[{"nameIdentifier":"707268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森田明典"}],"nameIdentifiers":[{"nameIdentifier":"707269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo"}],"nameIdentifiers":[{"nameIdentifier":"707270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"707271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"勝部 孝則","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 徹夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707278","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Effects from chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects from chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-02"},"publish_date":"2015-10-02","publish_status":"0","recid":"71834","relation_version_is_last":true,"title":["Effects from chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:46:50.068219+00:00"}