{"created":"2023-05-15T14:52:33.976470+00:00","id":71768,"links":{},"metadata":{"_buckets":{"deposit":"716cac6e-db8e-4cba-a67d-07ea26aa1f01"},"_deposit":{"created_by":1,"id":"71768","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71768"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071768","sets":["10:28"]},"author_link":["706393","706401","706409","706404","706400","706398","706397","706403","706405","706395","706406","706408","706396","706394","706407","706402","706399","706392"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"日本では糖尿病患者の95％以上が2型糖尿病といわれている。膵臓においてTryptophanはセロトニンの前駆物質としてインスリン分泌に関わり、また蛋白質合成にも関与している。我々は2型糖尿病モデルラット（ZDF-Leprfa/CrlCrlj）を用い、Tryptophanの類縁体である[11C]1-Methyl-L-tryptophan（[11C]L-Me-Trp）を合成し、その体内分布および病態との関連について検討した。ZDFラット（FattyおよびLean）は5～20週令を用い、経時的にPET、組織内放射能測定、血液生化学検査等を行った。[11C]L-Me-Trp投与後の放射能分布はFattyおよびLeanともに膵臓に高濃度を示した。Fattyの血糖値が上昇した12週において、膵臓の濃度はFatty 5週令の約1.7倍、Lean 12週令の約1.5倍高い値を示した。また同時期のFattyでは血漿中性脂肪も上昇していた。ARG法による膵臓内放射能分布はブロードで膵外分泌部への分布も観察された。これらのことからFattyにおける[11C]L-Me-Trpの膵臓への取り込み増加は、糖代謝および脂質代謝の異常に関わっていると示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"706392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"706393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"706394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"706395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"706396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田, 純"}],"nameIdentifiers":[{"nameIdentifier":"706397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"706398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"706399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"706400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706409","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"糖尿病モデルZDFラットを用いた[11C]1-Methyl-L-tryptophanのPETイメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病モデルZDFラットを用いた[11C]1-Methyl-L-tryptophanのPETイメージング"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-07-02"},"publish_date":"2015-07-02","publish_status":"0","recid":"71768","relation_version_is_last":true,"title":["糖尿病モデルZDFラットを用いた[11C]1-Methyl-L-tryptophanのPETイメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:47:36.674360+00:00"}