{"created":"2023-05-15T14:52:32.599935+00:00","id":71737,"links":{},"metadata":{"_buckets":{"deposit":"8ca14d20-edf0-40ef-b96d-8e0dbed560df"},"_deposit":{"created_by":1,"id":"71737","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71737"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071737","sets":["10:28"]},"author_link":["834472","834464","834476","834470","834477","834466","834471","834469","834468","834465","834475","834467","834474","834473"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-03-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Purpose: We have successfully visualized amyloid- (A) deposition in a mouse model of Alzheimer’s disease (AD) with the aid of newly developed amyloid imaging tracer 123/125I-DRM106, and suggested different binding site in aggregated A for this compound with popularly used amyloid imaging tracers such as PiB (Pittsburgh Compound B) in our previous study (J Nucl Med; 2015). In the present study, we have investigated the autoradiogram of radioiodinated DRM106 and other several amyloid imaging tracers in postmortem AD brain to examine the possibility of distinguishing different types of A deposits by combination of these tracers. \nMaterials & Methods: The AD brain sections containing the hippocampal and parahippocampal regions were incubated with radioactive tracers (11C-PiB; 5nM, 3H-AZD2184; 5nM, 125I-DRM106; 5nM) for 60 minutes, followed by consequent processes of autoradiographic analysis. Amyloid deposition was determined by fluorescent counterstaining with FSB and immunohistochemical staining with anti-A antibody (6E10).  \nResults: Autoradiographic images showed there is greatly difference in the feature of binding to brain subregions between tested tracers. There were greatly abundant binding sites for 11C-PiB and 3H-AZD2184, but not for 125I-DRM106, in the presubiculum of AD brain, where, abundant super-diffuse A deposits reacted with 6E10, was FSB-negative by fluorescent microscopic observation. These data indicate preferentiality of DRM106 to highly maturated A deposits compared with PiB and AZD2184.\nConclusions: The present result reveal possible contribution of those minor A pathology, such as super-diffuse plaques, to binding sites for these popularly used tracers, and it might be distinguishable by combination scans with different type amyloid imaging tracers such as PiB/AZD2184 and DRM106.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Japan-China Nuclear Medicine joint symposium in Okinawa ","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"BinJi"}],"nameIdentifiers":[{"nameIdentifier":"834464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chun-Jen, Chen"}],"nameIdentifiers":[{"nameIdentifier":"834465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bando, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"834466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ashino, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"834467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Maiko"}],"nameIdentifiers":[{"nameIdentifier":"834468","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamihisamatsu, Takeharu"}],"nameIdentifiers":[{"nameIdentifier":"834469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"834470","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"834471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ji, Bin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834472","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chun-Jen, Chen","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Maiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamihisamatsu, Takeharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834475","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834477","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Radiolabelling of Super-diffuse Amyloid-b Deposition with Popularly Used Amyloid Imaging Ligands in Postmortem Brain of Alzheimer’s Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiolabelling of Super-diffuse Amyloid-b Deposition with Popularly Used Amyloid Imaging Ligands in Postmortem Brain of Alzheimer’s Disease"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-02-19"},"publish_date":"2015-02-19","publish_status":"0","recid":"71737","relation_version_is_last":true,"title":["Radiolabelling of Super-diffuse Amyloid-b Deposition with Popularly Used Amyloid Imaging Ligands in Postmortem Brain of Alzheimer’s Disease"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:55:52.846285+00:00"}