{"created":"2023-05-15T14:52:32.244666+00:00","id":71729,"links":{},"metadata":{"_buckets":{"deposit":"1ad88c46-c4be-42a5-a726-8df86f9fe6b2"},"_deposit":{"created_by":1,"id":"71729","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71729"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071729","sets":["10:28"]},"author_link":["705907","705906","705908","705904","705905","705909"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-05-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Metallic radionuclides are widely used in nuclear medicine for both SPECT and PET imaging as well as for internal radiotherapy. Recently, radio-scandium is being focused as a potential radio-metal due to its favorable characteristic; particularly 43Sc has a moderate half-life of 3.9 h with enough emission rate of positron (88%), and 47Sc (–, 3.3 d) is a candidate for internal radiotherapy. These radio-scandiums can be produced from respective Ca target by using accelerated alpha particles, namely 40Ca(,x) or 44Ca(,n)-channel. In this study, we attempted to produce 43Sc remotely from natCaO target as a pilot case. \nMethods: A commercially available, 200 mg of natCaO (40Ca = 97 atom%) powder without further purification was loaded into a target vessel made of silicon carbide (SiC). The target vessel was covered by a 12.7 m Nb foil with O-ring, and placed at a vertical irradiation station. The non-self-supported target powder was able to keep its thickness by the force of gravity without any solidification process [1]. Irradiations were performed by NIRS AVF-930 cyclotron with 34 MeV alpha particles at 10 A for 2 h. After the irradiation, 0.5N-HCl was directly introduced into the target vessel to dissolve CaO target. Then, 6%-NH3 solution was similarly introduced into the target vessel to adjust pH of mixed solution at around 9, and recovered to the hotcell through a Teflon tubing (~15 m) by means of N2 pressure. The recovered solution was loaded into a chelating resin (InertSep ME2, 120 mg, GL Sciences, Japan) to trap 43Sc. The resin was washed with 0.05N-HCl to remove parasitic Ca2+; then 43Sc was eluted by 0.5N-HCl as the final product.\nResults: The yield of purified 43Sc was 1.04 GBq (28 mCi) which obtained within 1 h from EOB. Activity balance of the final product was reached to 75% of whole produced, and the radionuclidic purity of 43Sc showed 95% or higher till 17 h from EOB. By-produced nuclides found in the 43Sc product were, for example 44mSc(58.6 h, 0.0051% vs 43Sc), 44Sc(3.93 h, 3.2%), 46Sc(83.8 h, 0.0043%), and 47Sc(3.35 d, 0.034%) at 2 h from EOB. An estimation with a special emphasis on the production of 47Sc by using above result, the expected yield of 47Sc was 0.7 MBq (19 Ci)/Ah from enriched, i.e. 99 atom% 44Ca target. \nConclusion: 43Sc was remotely obtained by irradiation of natCaO that showed acceptable yield and purity, and this system can be applied to the production of 47Sc.\nAcknowledgements: The authors are grateful to the NIRS cyclotron staff for their excellent operation of AVF-930.\nReferences: [1] Nagatsu, K. et al. (2012) Nucl. Med. Biol. 39, 1281–1285","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"21st International Symposium on Radiopharmaceutical Sciences","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nagatsu, Koutarou"}],"nameIdentifiers":[{"nameIdentifier":"705904","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minegishi, Katsuyuki"}],"nameIdentifiers":[{"nameIdentifier":"705905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"705906","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永津 弘太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705907","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"峯岸 克行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705908","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705909","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A study on remote production of 43Sc from natCaO target via the natCa(,x)-reaction","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A study on remote production of 43Sc from natCaO target via the natCa(,x)-reaction"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-18"},"publish_date":"2015-06-18","publish_status":"0","recid":"71729","relation_version_is_last":true,"title":["A study on remote production of 43Sc from natCaO target via the natCa(,x)-reaction"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:48:01.903980+00:00"}