{"created":"2023-05-15T14:52:32.023421+00:00","id":71724,"links":{},"metadata":{"_buckets":{"deposit":"9ba6ed30-99be-422b-949e-d0665e076bef"},"_deposit":{"created_by":1,"id":"71724","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71724"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071724","sets":["10:28"]},"author_link":["705809","705811","705821","705823","705816","705818","705832","705833","705834","705828","705836","705815","705831","705812","705810","705827","705813","705822","705820","705835","705829","705808","705817","705830","705826","705819","705824","705814","705825","705837"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-05-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Translocator protein (18 kDa) (TSPO), a nucleus-encoded mitochondrial target transmembrane protein,\nhas been indicated as an active participant in the modulation of mitochondrial function. PET using radiolabeled TSPO\nprobes has allowed non-invasive and reliable investigation of TSPO in neuropathological damages of experimental\nanimals and humans. Many PET probes for TSPO imaging have been developed. Among them, [18F]FEDAC has\npotent binding affinity and selectivity for TSPO [1], high signal to neuroinflammation [2], and high sensitivity and\nspecificity for detection of fatty liver diseases progression [3]. We had previously synthesized [18F]FEDAC by reaction\nof desmethyl-precursor with [18F]fluoroethyl bromide at two steps using a modified 18F-labelling synthesizer\ndeveloped in our institute [1-3]. In this study, we simplified the synthesis of [18F]FEDAC by direct 18F-fluorination\nusing a typical 18F-labelling synthesizer to transfer the preparation of [18F]FEDAC to other institutes toward\nmulticenter clinical study.\nMethods: Tosylate-precursor for radiosynthesis of [18F]FEDAC was synthesized according to the procedures, as\nshown in Fig. 1. [18F]FEDAC was prepared by heating the tosylate-precursor with 18F- in DMSO at 110 ⁰C for 10-15\nmin.\nResults: Tosylate-precursor of [18F]FEDAC was successfully synthesized from desmethyl-precursor. [18F]FEDAC\nwas obtained with sufficient radioactivity and suitable quality for injection in clinical application. The synthesis of [18\nF]FEDAC was reproduceble to achieve >740 MBq, >300 GBq/μmol and >97% of radiochemical purity within 70 min of\nan overall synthesis time. All other analytical results were in compliance with our in-house quality control and\nassurance specifications.\nConclusions: We successfully synthesized [18F]FEDAC by fluorination of the tosylate-precursor with 18F- using onepot\n18F-labelling synthesizer. This radioligand will be used in clinical study.\nReferences: [1] Yanamoto K, et al (2009), Bioorg Med Chem Lett, 19, 1707-10. [2] Yui J, et al (2010), J Nucl Med, 51,\n1301-9. [3] Xie L, et al (2012), J Hepatol, 57, 1076-82.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"21st International Symposium on Radiopharmaceutical Sciences","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"705808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"705809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furutsuka, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"705810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiomi, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"705811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujishiro, Tomoya"}],"nameIdentifiers":[{"nameIdentifier":"705812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuji, Watanabe"}],"nameIdentifiers":[{"nameIdentifier":"705813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takei, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"705814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"705815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Takehito"}],"nameIdentifiers":[{"nameIdentifier":"705816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Masanao"}],"nameIdentifiers":[{"nameIdentifier":"705817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Igarashi, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"705818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Muto, Masatoshi"}],"nameIdentifiers":[{"nameIdentifier":"705819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki"}],"nameIdentifiers":[{"nameIdentifier":"705820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nemoto, Kazuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"705821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"705822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚 賢士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"潮見 聡","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤代 智也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 竜二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 裕輝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 岳人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"五十嵐 延行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤 正敏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根本 和義","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705837","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"One-pot radiosynthesis of [18F]FEDAC as a clinically applicable PET ligand for imaging TSPO.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"One-pot radiosynthesis of [18F]FEDAC as a clinically applicable PET ligand for imaging TSPO."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-15"},"publish_date":"2015-06-15","publish_status":"0","recid":"71724","relation_version_is_last":true,"title":["One-pot radiosynthesis of [18F]FEDAC as a clinically applicable PET ligand for imaging TSPO."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:48:05.479687+00:00"}