{"created":"2023-05-15T14:52:30.956653+00:00","id":71700,"links":{},"metadata":{"_buckets":{"deposit":"8f9bc571-d641-4781-b7cc-2fcce91942f8"},"_deposit":{"created_by":1,"id":"71700","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71700"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071700","sets":["10:28"]},"author_link":["705556","705549","705563","705554","705568","705552","705557","705553","705567","705542","705543","705562","705546","705540","705544","705558","705555","705561","705548","705551","705565","705539","705560","705569","705566","705564","705550","705541","705559","705547","705545"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-05-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"No.1001193\n【演題名】\nBrain metabolic correlates of tau accumulation in progressive supranuclear palsy\n【演題名(英文)】\nBrain metabolic correlates of tau accumulation in progressive supranuclear palsy\n【著者】\n古川彰吾1,2， 平野茂樹1,2， 島田斉1， 篠遠仁1,3， 佐原成彦1， 遠藤浩信1， 北村総一朗1， 丹羽文\n俊1， 高畑圭輔1， 木村泰之1， 山田真希子1,4， 張明栄5， 伊藤浩6,7， 樋口真人1， 桑原聡2， 須原\n哲也1\n【著者(英文)】\nShogo Furukawa1,2， Shigeki Hirano1,2， Hitoshi Shimada1， Hitoshi Shinotoh1,3， Naruhiko Sahara1，\nHironobu Endo1， Soichiro Kitamura1， Fumitoshi Niwa1， Keisuke Takahata1， Yasuyuki Kimura1，\nMakiko Yamada1,4， Ming-rong Zhang5， Hiroshi Ito6,7， Makoto Higuchi1， Satoshi Kuwabara2， Tetsuya\nSuhara1\n【所属】\n1放射線医学総合研究所分子神経イメージング研究プログラム， 2千葉大学大学院医学研究院神経内科\n学， 3神経内科千葉， 4科学技術振興機構　さきがけ， 5放射線医学総合研究所　分子認識研究プログラ\nム， 6放射線医学総合研究所　先端生体計測研究プログラム， 7福島県立医科大学　先端臨床研究セン\nター\n【所属(英文)】\n1Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences，\n2Department of Neurology, Graduate School of Medicine, Chiba University， 3Neurology Chiba Clinic，\n4Precursory Research for Embryonic Science and Technology, Japan Science and Technology， 5Molecular\nProbe Program,Molecular Imaging Center, National Institute of Radiological Sciences， 6Biophysics\nProgram,Molecular Imaging Center, National Institute of Radiological Sciences， 7Advanced Clinical Research\nCenter, Fukushima Medical University\nObjectives\nTo elucidate brain regions which is associated with cortical tau loads in progressive supranuclear palsy (PSP)\npatients by [11C]PBB and [18F]FDG PET.\nMethods:\nTen PSP patients [age: 70.2 (8.1),3 females, disease duration 4.6 (3.4) year, mean (SD)] were enrolled in the\npresent study. We performed [11C] PBB3 PET and [18F] FDG PET. Cortical tau load was calculated by\nstandardized uptake value ratio (SUVR) of [11C] PBB3 PET image using the cerebellar cortex as reference\nregion. Regional cerebral glucose metabolism was calculated by SUVR of [18F] FDG PET image and were\nanalyzed by statistical parametric mapping (spm8) with global normalization. Multiple regression whole brain\nanalysis was performed with cortical tau load as a covariate. Statistical threshold was determined as P < 0.005\nuncorrected, extent threshold 160 voxels.\nResults:\nNegative correlation between cortical tau load and regional cerebral glucose metabolism was detected in right\nanterior thalamus (Zmax = 3.45, voxel size 203).Positive correlation between cortical tau load and regional\ncerebral glucose metabolism was found in left paracentral lobule (Zmax = 4.39, voxel size 502) and right inferior\nparietal lobe (Zmax = 3.20, voxel size 225).\nConclusions:\nCortical tau load may explain thalamic dysfunction in PSP patients.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第56回日本神経学会学術大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Furukawa, Shogo"}],"nameIdentifiers":[{"nameIdentifier":"705539","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"705540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"705541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinotoh, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"705542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko"}],"nameIdentifiers":[{"nameIdentifier":"705543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Hironobu"}],"nameIdentifiers":[{"nameIdentifier":"705544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro"}],"nameIdentifiers":[{"nameIdentifier":"705545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Fumitoshi"}],"nameIdentifiers":[{"nameIdentifier":"705546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahata, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"705547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"705548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Makiko"}],"nameIdentifiers":[{"nameIdentifier":"705549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"705550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"705551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"705552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuwabara, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"705553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"705554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 彰吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐原 成彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤 浩信","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村 聡一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丹羽 文俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑 圭輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 真希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705569","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Brain metabolic correlates of tau accumulation in progressive supranuclear palsy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Brain metabolic correlates of tau accumulation in progressive supranuclear palsy"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-03"},"publish_date":"2015-06-03","publish_status":"0","recid":"71700","relation_version_is_last":true,"title":["Brain metabolic correlates of tau accumulation in progressive supranuclear palsy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:48:21.783150+00:00"}