@misc{oai:repo.qst.go.jp:00071700,
 author = {Furukawa, Shogo and Hirano, Shigeki and Shimada, Hitoshi and Shinotoh, Hitoshi and Sahara, Naruhiko and Endo, Hironobu and Kitamura, Soichiro and Niwa, Fumitoshi and Takahata, Keisuke and Kimura, Yasuyuki and Yamada, Makiko and Zhang, Ming-Rong and Ito, Hiroshi and Higuchi, Makoto and Kuwabara, Satoshi and Suhara, Tetsuya and 古川 彰吾 and 平野 成樹 and 島田 斉 and 篠遠 仁 and 佐原 成彦 and 遠藤 浩信 and 北村 聡一郎 and 丹羽 文俊 and 高畑 圭輔 and 木村 泰之 and 山田 真希子 and 張 明栄 and 伊藤 浩 and 樋口 真人 and 須原 哲也},
 month = {May},
 note = {No.1001193
【演題名】
Brain metabolic correlates of tau accumulation in progressive supranuclear palsy
【演題名(英文)】
Brain metabolic correlates of tau accumulation in progressive supranuclear palsy
【著者】
古川彰吾1,2， 平野茂樹1,2， 島田斉1， 篠遠仁1,3， 佐原成彦1， 遠藤浩信1， 北村総一朗1， 丹羽文
俊1， 高畑圭輔1， 木村泰之1， 山田真希子1,4， 張明栄5， 伊藤浩6,7， 樋口真人1， 桑原聡2， 須原
哲也1
【著者(英文)】
Shogo Furukawa1,2， Shigeki Hirano1,2， Hitoshi Shimada1， Hitoshi Shinotoh1,3， Naruhiko Sahara1，
Hironobu Endo1， Soichiro Kitamura1， Fumitoshi Niwa1， Keisuke Takahata1， Yasuyuki Kimura1，
Makiko Yamada1,4， Ming-rong Zhang5， Hiroshi Ito6,7， Makoto Higuchi1， Satoshi Kuwabara2， Tetsuya
Suhara1
【所属】
1放射線医学総合研究所分子神経イメージング研究プログラム， 2千葉大学大学院医学研究院神経内科
学， 3神経内科千葉， 4科学技術振興機構　さきがけ， 5放射線医学総合研究所　分子認識研究プログラ
ム， 6放射線医学総合研究所　先端生体計測研究プログラム， 7福島県立医科大学　先端臨床研究セン
ター
【所属(英文)】
1Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences，
2Department of Neurology, Graduate School of Medicine, Chiba University， 3Neurology Chiba Clinic，
4Precursory Research for Embryonic Science and Technology, Japan Science and Technology， 5Molecular
Probe Program,Molecular Imaging Center, National Institute of Radiological Sciences， 6Biophysics
Program,Molecular Imaging Center, National Institute of Radiological Sciences， 7Advanced Clinical Research
Center, Fukushima Medical University
Objectives
To elucidate brain regions which is associated with cortical tau loads in progressive supranuclear palsy (PSP)
patients by [11C]PBB and [18F]FDG PET.
Methods:
Ten PSP patients [age: 70.2 (8.1),3 females, disease duration 4.6 (3.4) year, mean (SD)] were enrolled in the
present study. We performed [11C] PBB3 PET and [18F] FDG PET. Cortical tau load was calculated by
standardized uptake value ratio (SUVR) of [11C] PBB3 PET image using the cerebellar cortex as reference
region. Regional cerebral glucose metabolism was calculated by SUVR of [18F] FDG PET image and were
analyzed by statistical parametric mapping (spm8) with global normalization. Multiple regression whole brain
analysis was performed with cortical tau load as a covariate. Statistical threshold was determined as P < 0.005
uncorrected, extent threshold 160 voxels.
Results:
Negative correlation between cortical tau load and regional cerebral glucose metabolism was detected in right
anterior thalamus (Zmax = 3.45, voxel size 203).Positive correlation between cortical tau load and regional
cerebral glucose metabolism was found in left paracentral lobule (Zmax = 4.39, voxel size 502) and right inferior
parietal lobe (Zmax = 3.20, voxel size 225).
Conclusions:
Cortical tau load may explain thalamic dysfunction in PSP patients., 第56回日本神経学会学術大会},
 title = {Brain metabolic correlates of tau accumulation in progressive supranuclear palsy},
 year = {2015}
}