{"created":"2023-05-15T14:52:24.059786+00:00","id":71545,"links":{},"metadata":{"_buckets":{"deposit":"60db8940-2f85-4672-a2d3-51e021aa55b7"},"_deposit":{"created_by":1,"id":"71545","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71545"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071545","sets":["10:28"]},"author_link":["703579","703577","703582","703581","703591","703586","703576","703590","703574","703583","703580","703585","703578","703588","703584","703589","703575","703587"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"過去10年、TSPOを標的としたPETプローブは神経炎症のマーカーとして、[11C]PK11195をはじめ数多く開発されてきたが、種差による特異結合の相違やbinder/non-binderの存在、緩慢な脳内動態などの問題に直面しているため、新しいTSPOプローブの開発は依然必要となっている。今回我々は、従来と全く異なる構造を有する[18F]PyBMPを開発し、ラット一過性脳虚血モデルを用いて、PETにより有用性を評価した。[18F]PyBMPは、ブロモ前駆体を18F-と 反応させることにより合成し、放射化学的収率(EOS)10%、合成時間62分(EOB)で得ることができた。PET実験の結果、虚血部位における放射能 集積は、対側正常部位に比べ約3倍高く、またその集積はPK11195の投与により完全に阻害されたことから、TSPOとの高い特異結合であることが証明 された。さらに同様のモデルを用いて[11C]PK11195と比較した結果、[18F]PyBMPの脳内動態は明らかに改善され、BPNDも高くなった。以上の結果から、[18F]PyBMPは神経炎症などの検出に極めて有用なPETプローブであることが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"703574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"703575","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"703576","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"703577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"703578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田, 陽子"}],"nameIdentifiers":[{"nameIdentifier":"703579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"703580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"703581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"703582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703587","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703588","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原 雄祐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703590","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703591","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"トランスロケータータンパク質(TSPO)PETプローブ[18F]PyBMPの合成と評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"トランスロケータータンパク質(TSPO)PETプローブ[18F]PyBMPの合成と評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-18"},"publish_date":"2014-11-18","publish_status":"0","recid":"71545","relation_version_is_last":true,"title":["トランスロケータータンパク質(TSPO)PETプローブ[18F]PyBMPの合成と評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:50:00.728892+00:00"}