{"created":"2023-05-15T14:52:23.974326+00:00","id":71543,"links":{},"metadata":{"_buckets":{"deposit":"19f43c10-732c-488f-9297-5647c710561c"},"_deposit":{"created_by":1,"id":"71543","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71543"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071543","sets":["10:28"]},"author_link":["703565","703560","703555","703551","703556","703554","703558","703562","703563","703559","703550","703553","703552","703557","703564","703561"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"「目的」トリプトファン(Trp)は必須アミノ酸の一種であり、その代謝変化をとらえる事は、疾患診断や機能解析に役立つと期待される。我々は、トリプトファン類似化合物として、インドール環の窒素原子に[11C]メチル基を導入した[11C]１-メチルトリプトファン([11C]MeTrp)の標識合成を行い、そのPET薬剤としての評価を行ったので報告する。\n「方法と結果」L体及びD体のBOC-Trp-OEtを標識原料としNaOH存在下、DMSO中で[11C]ヨウ化メチルと反応後、保護機を除去し目的物である２つの光学異性体の[11C]MeTrpを合成した。標識合成時の放射化学収率は約６０％（CO2基準）で放射化学純度は９５％以上であった。また両異性体の光学純度はキラルカラムLCより約９０％であった。ラット全身における放射能分布及びPET撮像では、立体異性により体内放射能分布に顕著な差が観察された。L体が膵臓に高集積を示したのに対しD体では膵臓にほとんど集積せず、腎臓から放射能の速やかな減少が見られた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"703550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"703551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"703552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"703553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"703554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"703555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田, 純"}],"nameIdentifiers":[{"nameIdentifier":"703556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"703557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原 雄祐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703565","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]１-メチルトリプトファンの標識合成と体内分布","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]１-メチルトリプトファンの標識合成と体内分布"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-17"},"publish_date":"2014-11-17","publish_status":"0","recid":"71543","relation_version_is_last":true,"title":["[11C]１-メチルトリプトファンの標識合成と体内分布"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:50:02.186808+00:00"}