{"created":"2023-05-15T14:52:23.888359+00:00","id":71541,"links":{},"metadata":{"_buckets":{"deposit":"8fff526e-5c67-4296-95e9-5cb810dddf7a"},"_deposit":{"created_by":1,"id":"71541","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71541"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071541","sets":["10:28"]},"author_link":["703526","703525","703523","703529","703532","703522","703527","703530","703524","703533","703534","703537","703535","703538","703539","703521","703536","703531","703520","703528"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】P-gp/BCRPは細胞内に取り込まれた薬物を排出する機能を持ち、抗がん剤等への耐性形成に寄与している。CEP-32496(1)はBRAF(V600E)変異に対し高い阻害活性をもつ抗がん薬であるが、P-gp/BCRPとの関係が不明である。本研究では[11C]COCl2を標識中間体に用い、ウレア骨格を有する新規 PETプローブ[11C]1を合成し、P-gp/BCRP欠損マウスを用いて評価した。【方法と結果】2種の標識原料及び1は市販原料より数工程で合成した。標識合成では標識原料イソオキサゾール誘導体を[11C]COCl2と反応させた後、キナゾリン誘導体を加え、[11C]1を14 ± 3%([11C]CO2からEOS) の放射化学収率で得た。合成時間はEOBより約35分であった。得られた[11C]1の放射化学的純度は98%以上で、比放射能は34-72 GBq/umolであった。マウス-PETでは、P-gp/BCRP欠損マウスの脳における放射能レベルの集積は野生型に比べ8倍高い値を示した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下田, 陽子"}],"nameIdentifiers":[{"nameIdentifier":"703520","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"703521","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"703522","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"703523","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"703524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"703525","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"703526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"703527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"703528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"703529","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703530","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703535","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703538","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703539","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"新規PETプローブ[11C]CEP-32496の合成とP-gp/BCRP欠損マウスにおける評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規PETプローブ[11C]CEP-32496の合成とP-gp/BCRP欠損マウスにおける評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-17"},"publish_date":"2014-11-17","publish_status":"0","recid":"71541","relation_version_is_last":true,"title":["新規PETプローブ[11C]CEP-32496の合成とP-gp/BCRP欠損マウスにおける評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:50:03.668428+00:00"}