{"created":"2023-05-15T14:52:20.758202+00:00","id":71469,"links":{},"metadata":{"_buckets":{"deposit":"d19136e9-4b72-40dd-b93c-62d6e497f04e"},"_deposit":{"created_by":1,"id":"71469","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71469"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071469","sets":["10:28"]},"author_link":["702712","702714","702713","702719","702716","702717","702721","702715","702720","702711","702710","702722","702718"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-09-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ビタミンEは脂溶性ビタミンであり、活性酸素種を効率よく消去することが知られている。本研究では活性酸素種のモデルとして2,2-diphenyl-1-picrylhydrazyl (DPPH)ラジカルを用い、ストップトフロー法によりビタミンE誘導体のラジカル消去活性に対するpHの影響について検討した。\nエタノール/水(9:1 v/v)混合溶媒中、25℃で、過剰量のTroloxとDPPHラジカルを反応させ、DPPHラジカルに由来する517 nmの吸光度の経時変化から擬一次速度定数を算出した後、二次反応速度定数を5.32 × 10(2) M(-1) s(-1)と決定した。この反応をエタノール/20 mMリン酸緩衝液(pH 6.0) (9:1 v/v)混合溶媒中で行うとTroloxの二次反応速度定数は7.95 × 10(2) M(-1) s(-1)と上昇し、エタノール/20 mMリン酸緩衝液(pH 7.0) (9:1 v/v)混合溶媒中では8.32 × 10(2) M(-1) s(-1)まで上昇した。これはpHの上昇に伴ってTroloxのフェノール性OH基の脱プロトン化が進行し、DPPHラジカルに対する電子移動が促進されたためと考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第67回日本酸化ストレス学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和氣, 司"}],"nameIdentifiers":[{"nameIdentifier":"702710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 敬"}],"nameIdentifiers":[{"nameIdentifier":"702711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 謙一郎"}],"nameIdentifiers":[{"nameIdentifier":"702712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"702713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福住, 俊一"}],"nameIdentifiers":[{"nameIdentifier":"702714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤, 俊彦"}],"nameIdentifiers":[{"nameIdentifier":"702715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西, 郁夫"}],"nameIdentifiers":[{"nameIdentifier":"702716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和氣 司","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702717","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤 俊彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702722","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ビタミンE誘導体のフリーラジカル消去活性に対するpHの影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ビタミンE誘導体のフリーラジカル消去活性に対するpHの影響"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-16"},"publish_date":"2014-06-16","publish_status":"0","recid":"71469","relation_version_is_last":true,"title":["ビタミンE誘導体のフリーラジカル消去活性に対するpHの影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:50:53.823237+00:00"}