{"created":"2023-05-15T14:52:19.250708+00:00","id":71434,"links":{},"metadata":{"_buckets":{"deposit":"a3c6bd7e-e00a-4956-8b1a-810939e76c9d"},"_deposit":{"created_by":1,"id":"71434","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71434"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071434","sets":["10:28"]},"author_link":["702340","702329","702337","702335","702339","702330","702336","702333","702334","702327","702338","702326","702331","702328","702332"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-03-25","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Recently, we have invented a high-throughput screening method for the examination of radioprotective activity of chemical compounds using thymocytes (Sekine, E.; et al. Anal Chem 85:7650-53; 2013). X-irradiation of the rat thymocytes induced apoptosis, leading to a significant cell shrinkage, which could be easily detected. \nMethods: The rats thymocytes were treated with/without antioxidants before/after 2 Gy X-irradiation.  The size of thymocytes were measured by flow cytometer 4 h after irradiation. We performed the radioprotector screening for (+)-catechin, epicatechin gallate, curcumin, resveratrol, vitamin C, vitamin E, caffeic acid, quercetin, Trolox, daidzein, genistein, carotene, and so on. Each antioxidant was applied for 1, 10, 100 μM, or 1 mM. \nResults and Conclusion: For the samples pretreated with antioxidants before irradiation, (+)-catechin (1 mM), epicatechin gallate (100 μ, 1 mM), curcumin (10 μM), resveratrol (100 μM), caffeic acid (100 μM, 1 mM), quercetin (1 mM), and Trolox (1 mM) efficiently protected the thymocytes against radiation-induced apoptosis. We also examined the samples treated with antioxidants after irradiation. The correlation between the radioprotective activity, as well as radiomitigable activity, and radical-scavenging rates of these antioxidants will be discussed based on the data obtained in this study.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"17th Biennial Meeting of Society for Free Radical Research International (SFRRI 2014)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関根, 絵美子"}],"nameIdentifiers":[{"nameIdentifier":"702326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"702327","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueno, Megumi"}],"nameIdentifiers":[{"nameIdentifier":"702328","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"702329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Ken-ichiro"}],"nameIdentifiers":[{"nameIdentifier":"702330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anzai, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"702331","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"702332","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"702333","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 絵美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702334","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 健","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702340","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Radioprotective and Radiomitigable Activity Screening of Natural Antioxidants and the Quantitative Evaluation ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radioprotective and Radiomitigable Activity Screening of Natural Antioxidants and the Quantitative Evaluation "}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-31"},"publish_date":"2014-03-31","publish_status":"0","recid":"71434","relation_version_is_last":true,"title":["Radioprotective and Radiomitigable Activity Screening of Natural Antioxidants and the Quantitative Evaluation "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:51:18.242008+00:00"}