{"created":"2023-05-15T14:52:15.285000+00:00","id":71346,"links":{},"metadata":{"_buckets":{"deposit":"9e582546-3809-43a9-bf2d-a9fd2570ec24"},"_deposit":{"created_by":1,"id":"71346","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71346"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071346","sets":["10:28"]},"author_link":["701541","701540","701539","701542","701546","701547","701549","701545","701543","701544","701548"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-12-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ABSTRACT       \nBackground: Interleukin-9 (IL-9) is a multifunctional cytokine secreted from Th2 cells. Besides its role in the immune and inflammatory responses, its growth promoting and antiapoptotic activities in multiple transformed cells suggest a potential role in tumorigenesis. The receptor of IL-9 (IL-9R) is not usually expressed in normal thymocytes except for fetal or newborn thymocytes.  We previously reported that IL-9R is unusually overexpressed and activated in radiation-induced mouse T-cell lymphomas (TL) which is an animal model of human T-cell acute lymphoblastic leukemia. These results suggest that IL-9R could be considered as an oncofetal antigen which could be used as a biomarker for diagnosis or treatment of T-cell leukemias. We have extended our study on the transcriptional regulation mechanism of IL-9R gene (Il9r).  \n\\nMaterials and Methods: We established an Il9r-highly-expressing TL cell line and examined the promoter activity with luciferase reporter assay. \n\\nResults and Discussion: We found that promoter regulatory region was located at a 5' AT-rich region from -410 bp to -487 bp upstream translation start site. The results from electrophoretic mobility shift assay (EMSA), liquid chromatography mass spectrometric mass spectrometry (LC-MS/MS) and chromatin immunoprecipitation (ChIP) assay revealed that the histone H4 is hyperacetylated and nucleolin was associated to the promoter region in lymphoma cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"KIDS workshop 2009 in NIRS - IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shang, Yi"}],"nameIdentifiers":[{"nameIdentifier":"701539","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"701540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"701541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Yoshiro"}],"nameIdentifiers":[{"nameIdentifier":"701542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"701543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"701544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"臺野 和広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"飯塚 大輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701549","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Regulation of IL-9R expression in T-cell lymphoma cell line","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of IL-9R expression in T-cell lymphoma cell line"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-11-14"},"publish_date":"2013-11-14","publish_status":"0","recid":"71346","relation_version_is_last":true,"title":["Regulation of IL-9R expression in T-cell lymphoma cell line"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:52:19.251637+00:00"}