@misc{oai:repo.qst.go.jp:00071346,
 author = {Shang, Yi and Kakinuma, Shizuko and Nishimura, Mayumi and Kobayashi, Yoshiro and Shimada, Yoshiya and et.al and 臺野 和広 and 今岡 達彦 and 飯塚 大輔 and 西村 まゆみ and 島田 義也},
 month = {Dec},
 note = {ABSTRACT       
Background: Interleukin-9 (IL-9) is a multifunctional cytokine secreted from Th2 cells. Besides its role in the immune and inflammatory responses, its growth promoting and antiapoptotic activities in multiple transformed cells suggest a potential role in tumorigenesis. The receptor of IL-9 (IL-9R) is not usually expressed in normal thymocytes except for fetal or newborn thymocytes.  We previously reported that IL-9R is unusually overexpressed and activated in radiation-induced mouse T-cell lymphomas (TL) which is an animal model of human T-cell acute lymphoblastic leukemia. These results suggest that IL-9R could be considered as an oncofetal antigen which could be used as a biomarker for diagnosis or treatment of T-cell leukemias. We have extended our study on the transcriptional regulation mechanism of IL-9R gene (Il9r).  
\nMaterials and Methods: We established an Il9r-highly-expressing TL cell line and examined the promoter activity with luciferase reporter assay. 
\nResults and Discussion: We found that promoter regulatory region was located at a 5' AT-rich region from -410 bp to -487 bp upstream translation start site. The results from electrophoretic mobility shift assay (EMSA), liquid chromatography mass spectrometric mass spectrometry (LC-MS/MS) and chromatin immunoprecipitation (ChIP) assay revealed that the histone H4 is hyperacetylated and nucleolin was associated to the promoter region in lymphoma cells., KIDS workshop 2009 in NIRS - IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children},
 title = {Regulation of IL-9R expression in T-cell lymphoma cell line},
 year = {2009}
}