{"created":"2023-05-15T14:52:15.241635+00:00","id":71345,"links":{},"metadata":{"_buckets":{"deposit":"58fee72c-cd3e-47c0-8de5-e77210eedf9c"},"_deposit":{"created_by":1,"id":"71345","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71345"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071345","sets":["10:28"]},"author_link":["701538","701536","701532","701533","701528","701529","701530","701534","701527","701535","701537","701526","701531"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-11-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】近年、発達期における放射線の影響について注目されているが、詳細な報告は少ない。そこで我々は、発達期および成体期における放射線被ばく時年齢依存性について、生体組織の中でも特に放射線感受性の高い腸管のアポトーシスを指標に比較し、発達期における放射線の急性影響について検討した。\n【材料と方法】発達期および成体期の腸管を比較検討するため、初めに胎児期18日齢〜生後7週齢の腸管をHE染色で形態学的に観察し、各発達段階における特徴を把握した。次に、授乳期（2週齢）および成体期（7週齢）でX線2Gyを全身照射し、照射後3時間、6時間、12時間、24時間における小腸ならびに大腸のアポトーシスをactive caspase3抗体染色により判定した。各群ともに雌雄3匹ずつ用い、apoptic index（half crypt当たりのアポトーシス細胞数）を測定した。\n【結果】形態学的観察の結果、胎児期や生後直後には認められなかったcrypt構造が、授乳期である2週齢では小さいサイズながらも認められ、成体期である7週齢では成熟した構造として観察された。次に2週齢と7週齢における放射線誘発アポトーシスを比較した予備的な実験では、アポトーシス細胞数がピークに達するまでの時間に差がみられた。現在我々は個体数を増やして解析を進めており、さらに詳細な結果を報告する。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第51回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今村, 智子"}],"nameIdentifiers":[{"nameIdentifier":"701526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼, 志津子"}],"nameIdentifiers":[{"nameIdentifier":"701527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上西, 睦美"}],"nameIdentifiers":[{"nameIdentifier":"701528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, 由希子"}],"nameIdentifiers":[{"nameIdentifier":"701529","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古渡, 礼恵"}],"nameIdentifiers":[{"nameIdentifier":"701530","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"701531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"701532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎 佳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂入 しのぶ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701535","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山内 一己","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701538","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"マウス腸管におけるアポトーシスの被ばく時年齢依存性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス腸管におけるアポトーシスの被ばく時年齢依存性"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-11-14"},"publish_date":"2013-11-14","publish_status":"0","recid":"71345","relation_version_is_last":true,"title":["マウス腸管におけるアポトーシスの被ばく時年齢依存性"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:52:19.947995+00:00"}