{"created":"2023-05-15T14:52:14.979173+00:00","id":71339,"links":{},"metadata":{"_buckets":{"deposit":"5c47855f-2bc1-4a98-b66e-346f9c40eedd"},"_deposit":{"created_by":1,"id":"71339","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71339"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071339","sets":["10:28"]},"author_link":["701477","701457","701459","701471","701461","701456","701462","701458","701467","701475","701472","701476","701463","701466","701468","701470","701464","701469","701460","701465","701474","701473"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-11-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　【目的】以前に我々が開発した覚醒・低拘束状態でマウスのPET計測が可能なマウス固定システムを用いて、[11C] racloprideによるPET計測における麻酔と拘束の影響を評価した。【方法】本固定システムを用いてのPET測定は、覚醒マウスの頭部のみを固定し、浮遊するボール上で体は自由に動かせる状態で行った。麻酔下の測定は、1.5％イソフルラン吸入下で行った。拘束下の測定は、覚醒マウスの頭部と腹部を固定し、体を自由に動かせない状態で測定を行った。PET測定は[11C] racloprideの静脈内投与後、90分間のダイナミック撮像を行った。【結果と考察】麻酔下と拘束下では、覚醒・低拘束状態と比べ線条体のドーパミンD2受容体結合能が有意に低かった。また、拘束下のマウスでは心拍数の増加が観察され、拘束によるストレスが生じていることが示唆された。PET計測時の麻酔と拘束は、内因性ドーパミンの放出を促進し、結合能を低下させる可能性がある。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第53回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田桑, 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順子"}],"nameIdentifiers":[{"nameIdentifier":"701464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野, 巖"}],"nameIdentifiers":[{"nameIdentifier":"701465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"701466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田桑 弘之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701468","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永 正希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701470","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701472","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川口 拓之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田島 洋佑","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷口 順子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701475","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野 巖","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 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