{"created":"2023-05-15T14:52:14.763850+00:00","id":71334,"links":{},"metadata":{"_buckets":{"deposit":"d1c5a4d7-d81c-4ad8-8348-5019e5256fb3"},"_deposit":{"created_by":1,"id":"71334","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71334"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071334","sets":["10:28"]},"author_link":["701389","701404","701388","701402","701390","701405","701396","701393","701399","701398","701394","701401","701391","701397","701403","701395","701400","701392"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-07-12","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は、化学物質の抗酸化能の評価を目的として、多数の候補化合物の中から効果の高いものを短時間でスクリーニングできる系を確立した（2012年3月27日特許出願（特願2012-72619）、2013年3月27日PCT 出願（PCT/JP2013/002032））。本法は、細胞障害因子によりラット胸腺細胞の細胞サイズが縮小する現象を利用しており、多数の化合物に関して生物効果の判定をすることができる。我々は、細胞障害因子として酸化ストレスの一つである放射線を用い、本法により、ＡＯＢ原末のミリＱ水抽出物とエタノール抽出物、ＡＯＢの成分であるダイゼイン、ゲニステイン、エピカテキン、エピガロカテキンガレート、ビタミンＣ、ビタミンＥ（α、β、γ、δ-トコフェロールおよびα、β、γ-トコトリエノール）、カロテンについて抗酸化能を検討してきた。本研究では、これらの抗酸化能を生物学的に評価するために、radio-modification factor (ＲＭＦ)として定量化して比較した。\nさらに、ＡＯＢ抽出物とＡＯＢ成分におけるＲＭＦ値と、各化合物の化学的なフリーラジカル消去能との相関についても検討を行ったので併せて報告する。本研究で得られた結果から、ＡＯＢの有効成分および詳細な抗酸化メカニズムを解明し、放射線防護剤への応用についても検討を行った。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第13回ＡＯＢ研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関根, 絵美子"}],"nameIdentifiers":[{"nameIdentifier":"701388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西, 郁夫"}],"nameIdentifiers":[{"nameIdentifier":"701389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和氣, 司"}],"nameIdentifiers":[{"nameIdentifier":"701390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野, 恵美"}],"nameIdentifiers":[{"nameIdentifier":"701391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川, 卓志"}],"nameIdentifiers":[{"nameIdentifier":"701392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 謙一郎"}],"nameIdentifiers":[{"nameIdentifier":"701393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"701394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"701395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 健"}],"nameIdentifiers":[{"nameIdentifier":"701396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 絵美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和氣 司","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 健","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701405","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ラット胸腺細胞を用いた抗酸化剤スクリーニングによるＡＯＢ成分の定量的活性評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット胸腺細胞を用いた抗酸化剤スクリーニングによるＡＯＢ成分の定量的活性評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-11-12"},"publish_date":"2013-11-12","publish_status":"0","recid":"71334","relation_version_is_last":true,"title":["ラット胸腺細胞を用いた抗酸化剤スクリーニングによるＡＯＢ成分の定量的活性評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:52:27.460500+00:00"}