{"created":"2023-05-15T14:52:13.799182+00:00","id":71312,"links":{},"metadata":{"_buckets":{"deposit":"410b4c6b-5f63-4dc0-bb4f-baf151011b34"},"_deposit":{"created_by":1,"id":"71312","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71312"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071312","sets":["10:28"]},"author_link":["701090","701085","701086","701089","701094","701087","701092","701095","701091","701093","701096","701088","701084","701097"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-18","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study is to establish carbon ion beam (C-ion) resistant cancer cells and to investigate the difference in cellular characteristics between C-ion resistant and X-ray resistant cancer cells. The X-ray resistant cancer cell was already established using mouse squamous cell carcinoma cell line NRS1. The cells were repeatedly irradiated with a total dose 60 Gy of 200 kVp X-ray, and this repetitive X-ray irradiation generated the X-ray resistant cancer cell NRS1-X60. Surprisingly the result from colony formation assay after irradiation of 290 MeV/n C-ion showed that NRS1-X60 cells also acquired significant C-ion resistance, Although C-ion irradiation is known to be more effective for killing cells of X-ray resistant tumor. The survival fractions of NRS1-X60 cells at 10 Gy of X-ray or 5 Gy of C-ion is approximately 6.3- or 6.7-folds increased compared with that in NRS1 cells, respectively. DNA repair potential in NRS1-X60 cells, which is represented by the disappearance of g-H2AX foci at one day after X-ray or C-ion irradiation, is promoted by approximately 2.3-fold compared with that in NRS1 cells for both irradiations. Currently, the NRS1 cells were repeatedly irradiated with a total dose 30 Gy of C-ion, and we established NRS1-C30 cells. We will report the difference in X-ray, C-ion sensitivity, and DNA repair potential between NRS1-X60, NRS1-C30, and NRS1.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Heavy Ion in Therapy and Space Radiation Symposium 2013 (HITSRS2013)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Katsutoshi"}],"nameIdentifiers":[{"nameIdentifier":"701084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"701085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakawatari, Miyako"}],"nameIdentifiers":[{"nameIdentifier":"701086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Etsuko"}],"nameIdentifiers":[{"nameIdentifier":"701087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moritake, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"701088","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"701089","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"701090","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 克俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 大介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701092","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡 美也子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 悦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森竹 浩之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701097","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Establishment and characterization of novel carbon-ion beam resistance cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Establishment and characterization of novel carbon-ion beam resistance cells"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-24"},"publish_date":"2013-10-24","publish_status":"0","recid":"71312","relation_version_is_last":true,"title":["Establishment and characterization of novel carbon-ion beam resistance cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:52:42.915565+00:00"}